Moderate exercise early after influenza virus infection reduces the Th1 inflammatory response in lungs of mice.

Moderate exercise early after influenza virus infection reduces the Th1 inflammatory response in lungs of mice. Research Abstract Details 

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Moderate exercise early after influenza virus infection reduces the Th1 inflammatory response in lungs of mice. Abstract Text:

Thomas Lowder,David A Padgett,Jeffrey A Woods,

We have previously shown that moderate exercise significantly increased survival after influenza virus (A/PR/8/34) infection in mice. We hypothesized that this brief duration of exercise would either increase innate immune defences and/or shift the immune response from a Th1 inflammatory to a Th2 anti-inflammatory response resulting in decreased lung pathology. Adult male BALB/cByJ mice (5-6 months old) were infected with 50 microL of A/PR/8/34 virus (40HAU) intranasally and randomized to either an exercise (EX) or sedentary (SED) group. EX mice performed 20-30 min of moderate exercise (8-12 m/min) on a motorized treadmill 4 hr post-infection and then exercised similarly for 4 consecutive days. SED mice were exposed to similar environmental conditions but did not exercise. Mice from both EX and SED groups were sacrificed 1, 3, or 5 days post-infection (p.i.) and lungs, mediastinal lymph nodes (MLNs) and spleens were harvested. EX significantly reduced total cellular infiltration and IFN-gamma gene expression in lungs at Days 3 and 5 p.i. and there was a qualitative shift in the expression of cytokines in the lung from a Th1 to a Th2 response. There was also a tendency toward a reduction in influenza M1 protein mRNA expression. There was no difference in IFN-beta protein levels between groups. These data suggest that moderate exercise when applied early after infection shifts the immune response away from a Th1 profile in mice infected with influenza virus. This exercise-induced shift in immune response may be responsible for improved survival after influenza virus infection.

Moderate exercise early after influenza virus infection reduces the Th1 inflammatory response in lungs of mice. Publishing Authors By Initials

T Lowder,DA Padgett,JA Woods,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, helper-inducer: th2 cells research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, helper-inducer: th2 cells research

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Moderate exercise early after influenza virus infection reduces the Th1 inflammatory response in lungs of mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Exercise immunology review

VOLUME: 12

Page Numbers: 97-111

Journal Abbreviation:

ISSN: 1077-5552

DAY: 3

MONTH: 12

YEAR: 2006

Moderate exercise early after influenza virus infection reduces the Th1 inflammatory response in lungs of mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9505535

Moderate exercise early after influenza virus infection reduces the Th1 inflammatory response in lungs of mice. Keywords Mesh Terms:

KEYWORDS: Th2 Cells

MESH TERMS: immunology

Chemical & Substance for Abstract: Moderate exercise early after influenza virus infection reduces the Th1 inflammatory response in lungs of mice. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Moderate exercise early after influenza virus infection reduces the Th1 inflammatory response in lungs of mice.

AFFILIATION: Department of Kinesiology, University of Illinois and Urbana-Champaign, Urbana, IL 61801, USA.

Country: Germany

AGENCY: United States NIA

GRANT: AG-13928

ACRONYM: AG

MEDLINETA: Exerc Immunol Rev

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