Models representing type I and type II human endometrial cancers: Ishikawa H and Hec50co cells.

Models representing type I and type II human endometrial cancers: Ishikawa H and Hec50co cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Models representing type I and type II human endometrial cancers: Ishikawa H and Hec50co cells. Abstract Text:

Lina Albitar,Gavin Pickett,Marilee Morgan,Suzy Davies,Kimberly K Leslie,

OBJECTIVE: Endometrial cancer models are critical to the advancement of investigation, and Ishikawa H and Hec50co cells have been used as research tools. The purpose of these studies is to verify the degree to which these commonly used cell models share the molecular characteristics of the two major in vivo endometrial cancer subtypes, I and II. METHODS: The studies reported include an analysis of pathologic features, tumor suppressor mutations, detailed karyotyping, and cell cycle regulation. RESULTS: Ishikawa H cells are hormone responsive and have lost PTEN expression. In addition they have lost RB1 expression due to a deletion in exon 9. Hec50co cells have lost p53 expression due to a deletion at the junction of exon 6 and intron 6-7. Compared to Ishikawa H cells, Hec50co cells harbor many more chromosomal rearrangements (29 versus seven), and the doubling time is more rapid. The percent of cells in each phase of the cell cycle is reported and linked to cell cycle regulators. CONCLUSION: We present extensive data indicating that Ishikawa H cells are excellent models for type I endometrial cancers, and Hec50co cells faithfully replicate the molecular characteristics of type II endometrial cancers. These studies allow testing of new therapeutic regimens using appropriate cell models.

Models representing type I and type II human endometrial cancers: Ishikawa H and Hec50co cells. Publishing Authors By Initials

L Albitar,G Pickett,M Morgan,S Davies,KK Leslie,

For similar proteins: dna-binding proteins: tumor suppressor protein p53 research abstracts see: proteins: dna-binding proteins: tumor suppressor protein p53 research

PUBMED ID PMID:

MEDLINE DATE:

Models representing type I and type II human endometrial cancers: Ishikawa H and Hec50co cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gynecologic oncology

VOLUME: 106

Page Numbers: 52-64

Journal Abbreviation: Gynecol. Oncol.

ISSN: 0090-8258

DAY: 8

MONTH: 05

YEAR: 2007

Models representing type I and type II human endometrial cancers: Ishikawa H and Hec50co cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 365304

Models representing type I and type II human endometrial cancers: Ishikawa H and Hec50co cells. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Protein p53

MESH TERMS: genetics

Chemical & Substance for Abstract: Models representing type I and type II human endometrial cancers: Ishikawa H and Hec50co cells. Information

Substance Name: Tumor Suppressor Protein p53

Registry Number: 0

Grant and Affiliation Information for Models representing type I and type II human endometrial cancers: Ishikawa H and Hec50co cells.

AFFILIATION: Obstetrics and Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The Cancer Research and Treatment Center, The University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01CA99908-1

ACRONYM: CA

MEDLINETA: Gynecol Oncol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Models representing type I and type II human endometrial cancers: Ishikawa H and Hec50co cells Related Publications

• 15-month-old infants detect violations in pretend scenarios.
• A common presentation with a rare cause.
• Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats.
• An evaluation of two indirect methods of estimating body weight in holstein calves and heifers.
• Anaesthesia for neurosurgery in the sitting position.
• Assessing penetration and aspiration: how do videofluoroscopy and fiberoptic endoscopic evaluation of swallowing compare?
• Challenges in improving fitness: results of a community-based, randomized, controlled lifestyle change intervention.
• Combining sequence and time series expression data to learn transcriptional modules.
• Consequences of the loss of p53, RB1, and PTEN: relationship to gefitinib resistance in endometrial cancer.
• Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons.
• Gestational exposure to nicotine and monoamine oxidase inhibitors influences cocaine-induced locomotion in adolescent rats.
• Involvement of alpha1-adrenergic receptors in tranylcypromine enhancement of nicotine self-administration in rat.
• Living in a Glasshouse... embracing care issues beyond ICU.
• Low dose nicotine treatment during early adolescence increases subsequent cocaine reward.
• Models representing type I and type II human endometrial cancers: Ishikawa H and Hec50co cells.
• One world, one medicine.
• Ovarian function in Holstein cows immunized against pregnant mare serum gonadotrophin.
• Plasma concentrations of luteinizing hormone and progesterone during superovulation of dairy cows using follicle stimulating hormone or pregnant mare serum gonadotrophin.
• Predicting genetic regulatory response using classification.
• Relationship of estrogen and progesterone receptors to clinical outcome in metastatic endometrial carcinoma: a Gynecologic Oncology Group Study.
• Relative severity of aflatoxin contamination of cereal crops in West Africa.
• SVM-Fold: a tool for discriminative multi-class protein fold and superfamily recognition.
• Sample size requirements for bone density precision assessments and effect on patient categorization: a Monte Carlo simulation study.
• Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN.
• Synchronization of estrus and pregnancy risk in anestrous dairy cows after treatment with a progesterone-releasing intravaginal device.
• Targeted treatment using monoclonal antibodies and tyrosine-kinase inhibitors in pregnancy.
• The conceptual underpinnings of pretense: pretending is not 'behaving-as-if'.
• The role of advanced practice clinicians in the availability of abortion services in the United States.
• Timing of the onset and duration of ovulation in superovulated beef heifers.
• Type 1 diabetes and latent autoimmune diabetes in adults.