Modeling intercellular interactions in early Mycobacterium infection.

Modeling intercellular interactions in early Mycobacterium infection. Research Abstract Details 

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Modeling intercellular interactions in early Mycobacterium infection. Abstract Text:

Christina Warrender,Stephanie Forrest,Frederick Koster,

Infection with Mycobacterium tuberculosis (Mtb) is characterized by localized, roughly spherical lesions within which the pathogen interacts with host cells. Containment of the infection or progression of disease depends on the behavior of individual cells, which, in turn, depends on the local molecular environment and on contact with neighboring cells. Modeling can help us understand the nonlinear interactions that drive the overall dynamics in this system. Early events in infection are particularly important, as are spatial effects and inherently stochastic processes. We describe a model of early Mycobacterium infection using the CyCells simulator, which was designed to capture these effects. We relate CyCells simulations of the model to several experimental observations of individual components of the response to Mtb.

Modeling intercellular interactions in early Mycobacterium infection. Publishing Authors By Initials

C Warrender,S Forrest,F Koster,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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Modeling intercellular interactions in early Mycobacterium infection. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Bulletin of mathematical biology

VOLUME: 68

Page Numbers: 2233-61

Journal Abbreviation: Bull. Math. Biol.

ISSN: 0092-8240

DAY: 20

MONTH: 05

YEAR: 2006

Modeling intercellular interactions in early Mycobacterium infection. Information

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LANGUAGE: eng

NlmUniqueID: 401404

Modeling intercellular interactions in early Mycobacterium infection. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: immunology

Chemical & Substance for Abstract: Modeling intercellular interactions in early Mycobacterium infection. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Modeling intercellular interactions in early Mycobacterium infection.

AFFILIATION: Department of Computer Science, University of New Mexico, P.O. Box 5800 MS 1423, Albuquerque, NM 87185-1423, USA. cewarr@sandia.gov

Country: United States

AGENCY: United States NIAID

GRANT: U54 AI057156

ACRONYM: AI

MEDLINETA: Bull Math Biol

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