Modeling cardiac ischemia.

Modeling cardiac ischemia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Modeling cardiac ischemia. Abstract Text:

Blanca ,Natalia Trayanova,Denis Noble,

Myocardial ischemia is one of the main causes of sudden cardiac death, with 80% of victims suffering from coronary heart disease. In acute myocardial ischemia, the obstruction of coronary flow leads to the interruption of oxygen flow, glucose, and washout in the affected tissue. Cellular metabolism is impaired and severe electrophysiological changes in ionic currents and concentrations ensue, which favor the development of lethal cardiac arrhythmias such as ventricular fibrillation. Due to the burden imposed by ischemia in our societies, a large body of research has attempted to unravel the mechanisms of initiation, sustenance, and termination of cardiac arrhythmias in acute ischemia, but the rapidity and complexity of ischemia-induced changes as well as the limitations in current experimental techniques have hampered evaluation of ischemia-induced alterations in cardiac electrical activity and understanding of the underlying mechanisms. Over the last decade, computer simulations have demonstrated the ability to provide insight, with high spatiotemporal resolution, into ischemic abnormalities in cardiac electrophysiological behavior from the ionic channel to the whole organ. This article aims to review and summarize the results of these studies and to emphasize the role of computer simulations in improving the understanding of ischemia-related arrhythmias and how to efficiently terminate them.

Modeling cardiac ischemia. Publishing Authors By Initials

B ,N Trayanova,D Noble,

For similar cardiovascular diseases: heart diseases: myocardial ischemia research abstracts see: cardiovascular diseases: heart diseases: myocardial ischemia research

PUBMED ID PMID:

MEDLINE DATE:

Modeling cardiac ischemia. Journal Published:

PUBLICATION TYPE: Review

Journal: Annals of the New York Academy of Sciences

VOLUME: 1080

Page Numbers: 395-414

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 3

MONTH: Oct

YEAR: 2006

Modeling cardiac ischemia. Information

Number of References: 96

LANGUAGE: eng

NlmUniqueID: 7506858

Modeling cardiac ischemia. Keywords Mesh Terms:

KEYWORDS: Myocardial Ischemia

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Modeling cardiac ischemia. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Modeling cardiac ischemia.

AFFILIATION: Oxford University Computing Laboratory, Wolfson Building, Parks Road, Oxford, UK. blanca@comlab.ox.ac.uk

Country: United States

AGENCY: United States NHLBI

GRANT: HL 63195

ACRONYM: HL

MEDLINETA: Ann N Y Acad Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Modeling cardiac ischemia Related Publications

• A field study of the fertility of transported equine semen.
• A structural alignment kernel for protein structures.
• Benefits of sign language interpreting and text alternatives for deaf students' classroom learning.
• Blockade of chronic graft-versus-host disease by alloantigen-induced CD4+CD25+Foxp3+ regulatory T cells in nonlymphopenic hosts.
• CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo.
• Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function.
• Comment on "Discrimination of shifts in a soil microbial community associated with TNT-contamination using a functional ANOVA of 16S rRNA hybridized to oligonucleotide microarrays".
• Detection of estrus with cows administered testosterone via injections and/or silastic implants.
• Development of a statistically robust quantification method for microorganisms in mixtures using oligonucleotide microarrays.
• Does external evaluation of laboratories improve patient safety?
• Ethics in the trenches: a multifaceted analysis of the stem cell debate.
• High variability in melting profiles from gel pad arrays.
• Hyaluronan in tissue injury and repair.
• Long term effects of early nutritional support with new enterotropic peptide-based formula vs. standard enteral formula in HIV-infected patients: randomised prospective trial Chlebowski R T, Beall G, Grovenor M, Lillington L, Weintraub N, Ambler C, Richar
• Modeling cardiac ischemia.
• Mutations of the betaN102 residue of HbA not only inhibit the ligand-linked T to Re state transition, but also profoundly affect the properties of the T state itself.
• Noninhibitory PAI-1 enhances plasmin-mediated matrix degradation both in vitro and in experimental nephritis.
• Oligonucleotide microarrays: widely applied--poorly understood.
• PAI-1 as a target in kidney disease.
• Revision of the nonequilibrium thermal dissociation and stringent washing approaches for identification of mixed nucleic acid targets by microarrays.
• Speech perception and localization with adults with bilateral sequential cochlear implants.
• Support vector machine learning from heterogeneous data: an empirical analysis using protein sequence and structure.
• The evidence base of palliative medicine: is inpatient palliative medicine evidence-based?
• The genetic transmission of alcoholism: implications for prevention.
• The maturation of rat brain myelin.
• The role of Toll-like receptors in non-infectious lung injury.
• The role of growth factors and related agents in accelerating fracture healing.
• Unsupervised segmentation of continuous genomic data.
• Use of forensic DNA evidence in prosecutors'offices.
• [Constituents of the essential oil of myrrh.]