Modeling baroreflex regulation of heart rate during orthostatic stress.

Modeling baroreflex regulation of heart rate during orthostatic stress. Research Abstract Details 

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Modeling baroreflex regulation of heart rate during orthostatic stress. Abstract Text:

Mette S Olufsen,Hien T Tran,Johnny T Ottesen, ,Lewis A Lipsitz,Vera Novak,

During orthostatic stress, arterial and cardiopulmonary baroreflexes play a key role in maintaining arterial pressure by regulating heart rate. This study presents a mathematical model that can predict the dynamics of heart rate regulation in response to postural change from sitting to standing. The model uses blood pressure measured in the finger as an input to model heart rate dynamics in response to changes in baroreceptor nerve firing rate, sympathetic and parasympathetic responses, vestibulo-sympathetic reflex, and concentrations of norepinephrine and acetylcholine. We formulate an inverse least squares problem for parameter estimation and successfully demonstrate that our mathematical model can accurately predict heart rate dynamics observed in data obtained from healthy young, healthy elderly, and hypertensive elderly subjects. One of our key findings indicates that, to successfully validate our model against clinical data, it is necessary to include the vestibulo-sympathetic reflex. Furthermore, our model reveals that the transfer between the nerve firing and blood pressure is nonlinear and follows a hysteresis curve. In healthy young people, the hysteresis loop is wide, whereas, in healthy and hypertensive elderly people, the hysteresis loop shifts to higher blood pressure values, and its area is diminished. Finally, for hypertensive elderly people, the hysteresis loop is generally not closed, indicating that, during postural change from sitting to standing, baroreflex modulation does not return to steady state during the first minute of standing.

Modeling baroreflex regulation of heart rate during orthostatic stress. Publishing Authors By Initials

MS Olufsen,HT Tran,JT Ottesen, ,LA Lipsitz,V Novak,

For similar natural sciences: science: models, theoretical research abstracts see: natural sciences: science: models, theoretical research

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Modeling baroreflex regulation of heart rate during orthostatic stress. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of physiology. Regulatory, integr

VOLUME: 291

Page Numbers: R1355-68

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 22

MONTH: 06

YEAR: 2006

Modeling baroreflex regulation of heart rate during orthostatic stress. Information

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LANGUAGE: eng

NlmUniqueID: 100901230

Modeling baroreflex regulation of heart rate during orthostatic stress. Keywords Mesh Terms:

KEYWORDS: Models, Theoretical

MESH TERMS: physiopathology

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Grant and Affiliation Information for Modeling baroreflex regulation of heart rate during orthostatic stress.

AFFILIATION: Dept. of Mathematics, North Carolina State Univ., Campus Box 8205, Raleigh, NC 27695, USA. msolufse@math.ncsu.edu

Country: United States

AGENCY: United States NINDS

GRANT: R01-NS-045745-01A2

ACRONYM: NS

MEDLINETA: Am J Physiol Regul Integr Comp

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