Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigens.

Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigens. Research Abstract Details 

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Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigens. Abstract Text:

Fan Yang,Irene H Chen,Zeyu Xiong,Yan Yan,Hong Wang,Xiao-Feng Yang,

We recently proposed a novel model of stimulation-responsive splicing for the selection of autoantigens and self-tumor antigens. Our model theorizes that the significantly higher rates of alternative splicing of autoantigen and self-tumor antigen transcripts that occur in response to stimuli could induce extra-thymic expression of untolerized antigen epitopes for elicitation of autoimmune and anti-tumor responses. To facilitate the identification of immunogenic isoforms of antigens, we have developed strategies using improved SEREX in conjunction with database-mining and immunogenic isoform mapping. Identification of immunogenic isoforms of autoantigens and self-tumor antigens is very important for the development of novel therapeutics and diagnostic tools for autoimmune diseases and tumors, such as: (1) autoantigen isoform microarrays for disease diagnosis and prognosis; (2) autoantigen isoform-specific tolerizing vaccines and splicing-redirection therapies, as well as (3) immunogenic antigen isoform-specific immunotherapy for tumors.

Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigens. Publishing Authors By Initials

F Yang,IH Chen,Z Xiong,Y Yan,H Wang,XF Yang,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigens. Journal Published:

PUBLICATION TYPE: Review

Journal: Clinical immunology (Orlando, Fla.)

VOLUME: 121

Page Numbers: 121-33

Journal Abbreviation: Clin. Immunol.

ISSN: 1521-6616

DAY: 4

MONTH: 08

YEAR: 2006

Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigens. Information

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LANGUAGE: eng

NlmUniqueID: 100883537

Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigens. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: genetics

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Substance Name: Proteome

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Grant and Affiliation Information for Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigens.

AFFILIATION: Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Medical Research Building, Suite 300, Philadelphia, PA 19140, USA. xfyang@temple.edu

Country: United States

AGENCY: United States NIAID

GRANT: AI054514

ACRONYM: AI

MEDLINETA: Clin Immunol

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