Model for the regulation of size in the wing imaginal disc of Drosophila.

Model for the regulation of size in the wing imaginal disc of Drosophila. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Model for the regulation of size in the wing imaginal disc of Drosophila. Abstract Text:

Tinri Aegerter-Wilmsen,Christof M Aegerter,Ernst Hafen,Konrad Basler,

For animal development it is necessary that organs stop growing after they reach a certain size. However, it is still largely unknown how this termination of growth is regulated. The wing imaginal disc of Drosophila serves as a commonly used model system to study the regulation of growth. Paradoxically, it has been observed that growth occurs uniformly throughout the disc, even though Decapentaplegic (Dpp), a key inducer of growth, forms a gradient. Here, we present a model for the control of growth in the wing imaginal disc, which can account for the uniform occurrence and termination of growth. A central feature of the model is that net growth is not only regulated by growth factors, but by mechanical forces as well. According to the model, growth factors like Dpp induce growth in the center of the disc, which subsequently causes a tangential stretching of surrounding peripheral regions. Above a certain threshold, this stretching stimulates growth in these peripheral regions. Since the stretching is not completely compensated for by the induced growth, the peripheral regions will compress the center of the disc, leading to an inhibition of growth in the center. The larger the disc, the stronger this compression becomes and hence the stronger the inhibiting effect. Growth ceases when the growth factors can no longer overcome this inhibition. With numerical simulations we show that the model indeed yields uniform growth. Furthermore, the model can also account for other experimental data on growth in the wing disc.

Model for the regulation of size in the wing imaginal disc of Drosophila. Publishing Authors By Initials

T Aegerter-Wilmsen,CM Aegerter,E Hafen,K Basler,

For similar animal structures: forelimb: wing research abstracts see: animal structures: forelimb: wing research

PUBMED ID PMID:

MEDLINE DATE:

Model for the regulation of size in the wing imaginal disc of Drosophila. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Mechanisms of development

VOLUME: 124

Page Numbers: 318-26

Journal Abbreviation: Mech. Dev.

ISSN: 0925-4773

DAY: 29

MONTH: 12

YEAR: 2006

Model for the regulation of size in the wing imaginal disc of Drosophila. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9101218

Model for the regulation of size in the wing imaginal disc of Drosophila. Keywords Mesh Terms:

KEYWORDS: Wing

MESH TERMS: growth & development

Chemical & Substance for Abstract: Model for the regulation of size in the wing imaginal disc of Drosophila. Information

Substance Name: dpp protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for Model for the regulation of size in the wing imaginal disc of Drosophila.

AFFILIATION: Zoological Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Country: Ireland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mech Dev

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Model for the regulation of size in the wing imaginal disc of Drosophila Related Publications

• A Proteome Catalog of Drosophila melanogaster: An Essential Resource for Targeted Quantitative Proteomics.
• A five-amino-Acid deletion of the eastern equine encephalitis virus capsid protein attenuates replication in Mammalian systems but not in mosquito cells.
• Capsid protein of eastern equine encephalitis virus inhibits host cell gene expression.
• Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins.
• Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.
• Evidence for a "new" allele at the esterase D (E.C. 3.1.1.1.) locus.
• Influenza virus pathogenesis and drug targets.
• Influenza viruses: basic biology and potential drug targets.
• Minocycline-related hyperpigmentation.
• Model for the regulation of size in the wing imaginal disc of Drosophila.
• Multiple health risk behaviors in German first year university students.
• Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization.
• On recent observations in the rhesus blood group system. I. A weak expression of the Rh antigen e. II. Finding of the rare Rh antigen Cx.
• Potential hazards of clindamycin in acne therapy.
• Recombinases and their use in gene activation, gene inactivation, and transgenesis.
• Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila.
• Signal-induced repression: the exception or the rule in developmental signaling?
• The Pain Attitudes and Beliefs Scale for Physiotherapists: psychometric properties of the German version.
• The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family.
• The forensic application of the blood group antigens Lua and Lub.
• Ultrasonic phased-array scanner with digital echo synthesis for Doppler echocardiography.
• Wingless secretion promotes and requires retromer-dependent cycling of Wntless.
• Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.
• [AMIKA: psychometric evaluation of a photo-based scale for the assessment of fear avoidance beliefs in elderly individuals]
• [Are nursing standards threatened by an inadmissible reduction?]
• [Chronification process of backache]
• [In Process Citation]
• [Psychological pain treatment in rheumatic patients.]
• [Testing of refuse disposal at a nursing station. "The Zieglerspital is exemplary". Interview by Fred Arm.]
• [Unequal crossing-over as a possible cause of blood group serologic phenomena]