Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach.

Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. Research Abstract Details 

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Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. Abstract Text:

Robert J Coffey,Mary Kay Washington,Christopher L Corless,Michael C Heinrich,

Ménétrier disease and gastrointestinal stromal tumors (GISTs) are hyperproliferative disorders of the stomach caused by dysregulated receptor tyrosine kinases (RTKs). In Ménétrier disease, overexpression of TGF-alpha, a ligand for the RTK EGFR, results in selective expansion of surface mucous cells in the body and fundus of the stomach. In GISTs, somatic mutations of the genes encoding the RTK KIT (or PDGFRA in a minority of cases) result in constitutive kinase activity and neoplastic transformation of gut pacemaker cells (interstitial cells of Cajal). On the basis of the involvement of these RTKs in the pathogenesis of these disorders, Ménétrier disease patients have been effectively treated with a blocking monoclonal antibody specific for EGFR and GIST patients with KIT and PDGFRA tyrosine kinase inhibitors.

Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. Publishing Authors By Initials

RJ Coffey,MK Washington,CL Corless,MC Heinrich,

For similar neoplasms: neoplasms by site: digestive system neoplasms: gastrointestinal neoplasms: stomach neoplasms research abstracts see: neoplasms: neoplasms by site: digestive system neoplasms: gastrointestinal neoplasms: stomach neoplasms research

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Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of clinical investigation

VOLUME: 117

Page Numbers: 70-80

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 3

MONTH: Jan

YEAR: 2007

Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. Information

Number of References: 108

LANGUAGE: eng

NlmUniqueID: 7802877

Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. Keywords Mesh Terms:

KEYWORDS: Stomach Neoplasms

MESH TERMS: pathology

Chemical & Substance for Abstract: Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. Information

Substance Name: Protein-Tyrosine Kinases

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach.

AFFILIATION: Department of Medicine, Vanderbilt University Medical Center and Nashville Veterans Affairs Medical Center, Nashville, Tennessee, USA. robert.coffey@vanderbilt.edu

Country: United States

AGENCY: United States NCI

GRANT: P50 CA95103

ACRONYM: CA

MEDLINETA: J Clin Invest

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