MMPs in the central nervous system: Where the good guys go bad.

MMPs in the central nervous system: Where the good guys go bad. Research Abstract Details 

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MMPs in the central nervous system: Where the good guys go bad. Abstract Text:

Smriti M Agrawal,Lorraine Lau,V Wee Yong,Smriti M Agrawal,Lorraine Lau,V Wee Yong,

Matrix metalloproteinases (MMPs) are expressed in the developing, healthy adult and diseased CNS. We emphasize the regulation of neurogenesis and oligodendrogenesis by MMPs during CNS development, and highlight physiological roles of MMPs in the healthy adult CNS, such as in synaptic plasticity, learning and memory. Nonetheless, MMPs as "the good guys" go bad in neurological conditions, likely aided by the sudden and massive upregulation of several MMP members. We stress the necessity of drawing a fine balance in the treatment of neurological diseases, and we suggest that MMP inhibitors do have therapeutic potential early after CNS injury.

MMPs in the central nervous system: Where the good guys go bad. Publishing Authors By Initials

SM Agrawal,L Lau,VW Yong,SM Agrawal,L Lau,VW Yong,

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MMPs in the central nervous system: Where the good guys go bad. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Seminars in cell & developmental biology

VOLUME: 19

Page Numbers: 42-51

Journal Abbreviation: Semin. Cell Dev. Biol.

ISSN: 1084-9521

DAY: 19

MONTH: 06

YEAR: 2007

MMPs in the central nervous system: Where the good guys go bad. Information

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LANGUAGE: eng

NlmUniqueID: 9607332

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Grant and Affiliation Information for MMPs in the central nervous system: Where the good guys go bad.

AFFILIATION: Hotchkiss Brain Institute and the Departments of Clinical Neuroscience and Oncology, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta T2N 4N1, Canada.

Country: England

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MEDLINETA: Semin Cell Dev Biol

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