[MMP-2/TIMP-2 expression in the trophoblasts of patients with gestational trophoblastic disease]

[MMP-2/TIMP-2 expression in the trophoblasts of patients with gestational trophoblastic disease] Research Abstract Details 

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[MMP-2/TIMP-2 expression in the trophoblasts of patients with gestational trophoblastic disease] Abstract Text:

Feng Ding,Qiu-Shi Zhang,Fu-Qi Xing,

OBJECTIVE: To explore the role of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of MMP-2 (TIMP-2) in the pathogenesis, development and prognosis of gestational trophoblastic disease (GTD). METHODS: In situ hybridization and immunohistochemistry were utilized for MMP-2/TIMP-2 mRNA and protein detection in normal chorion of women with early gestation, hydatidiform mole, invasive mole, or choricarcinoma. RESULTS: The results revealed that specific staining for mRNA and protein of MMP-2 and the expression of TIMP-2 was reduced in normal chorion of early gestation. In GTD ranging from hydatidiform mole, invasive mole to choricarcinoma, MMP-2 expression tended to increase while TIMP-2 expression underwent an invert change. The positivity rate of MMP-2 and TIMP-2 in gestational trophoblastic tumor group was higher than that of the normal chorion of early gestation group and hydatiform mole group (P<0.05 and P<0.001, respectively). CONCLUSION: A disrupted balance between the activation and inhibition of MMP-2 plays a critical role in the pathogenesis, progression and metastasis of GTD.

[MMP-2/TIMP-2 expression in the trophoblasts of patients with gestational trophoblastic disease] Publishing Authors By Initials

F Ding,QS Zhang,FQ Xing,

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[MMP-2/TIMP-2 expression in the trophoblasts of patients with gestational trophoblastic disease] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nan fang yi ke da xue xue bao = Journal of Souther

VOLUME: 27

Page Numbers: 150-2

Journal Abbreviation: Nan Fang Yi Ke Da Xue Xue Bao

ISSN: 1673-4254

DAY: 14

MONTH: Feb

YEAR: 2007

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LANGUAGE: chi

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AFFILIATION: Postdocboral Station, Sun Yet-sen University, Guangzhou 510120, China. dfsyw@sina.com

Country: China

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MEDLINETA: Nan Fang Yi Ke Da Xue Xue Bao

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