MMP-2 assessment as an indicator of wound healing: A feasibility study.

MMP-2 assessment as an indicator of wound healing: A feasibility study. Research Abstract Details 

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MMP-2 assessment as an indicator of wound healing: A feasibility study. Abstract Text:

Refaat B Karim,Beatriz L R Brito,Richard P Dutrieux,Fernanda P Lassance,J Joris Hage,

OBJECTIVE: Evaluate the feasibility of assessment of fibroblast matrix metalloproteinase-2 (MMP-2) expression as an indicator of wound healing in wounds that change from chronically inert to actively healing. METHODS: Phase II feasibility study of 4 patients with nonhealing wounds (duration, > or = 3 months; surface area, > or = 1 cm). Wounds were treated with a dressing impregated with oak bark extract (DerMax) and evaluated weekly; biopsies were performed every 2 weeks until wound healing. RESULTS: Therapy-induced wound healing and immunohistochemical measurements of MMP-2 expression paralleled the clinical characteristics of wound healing. CONCLUSION: MMP-2 expression offers a reliable indicator for clinical wound healing induced by DerMax treatment.

MMP-2 assessment as an indicator of wound healing: A feasibility study. Publishing Authors By Initials

RB Karim,BL Brito,RP Dutrieux,FP Lassance,JJ Hage,

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MMP-2 assessment as an indicator of wound healing: A feasibility study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Advances in skin & wound care

VOLUME: 19

Page Numbers: 324-7

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ISSN: 1527-7941

DAY: 3

MONTH: 12

YEAR: 2007

MMP-2 assessment as an indicator of wound healing: A feasibility study. Information

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LANGUAGE: eng

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Grant and Affiliation Information for MMP-2 assessment as an indicator of wound healing: A feasibility study.

AFFILIATION: Department of Plastic and Reconstructive Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands.

Country: United States

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MEDLINETA: Adv Skin Wound Care

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