MKK4 status predicts survival after resection of gastric adenocarcinoma.

MKK4 status predicts survival after resection of gastric adenocarcinoma. Research Abstract Details 

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MKK4 status predicts survival after resection of gastric adenocarcinoma. Abstract Text:

Steven C Cunningham,Farin Kamangar,Min P Kim,Sommer Hammoud,Raqeeb Haque,Christine Iacobuzio-Donahue,Raheela Ashfaq,Scott E Kern,Anirban Maitra,Richard E Heitmiller,Michael A Choti,Keith D Lillemoe,John L Cameron,Charles J Yeo,Elizabeth Montgomery,Richard D Schulick,

HYPOTHESIS: Lack of expression of the tumor-suppressor gene MKK4 is significantly correlated with poor survival after resection of gastric adenocarcinoma. DESIGN: Retrospective review of medical records after construction and immunolabeling of tissue microarrays for clinical correlation. SETTING: The Johns Hopkins Hospital, Baltimore, Md. PATIENTS: Patients operated on because of gastric adenocarcinoma between 1983 and 1995. Main Outcome Measure Long-term survival and MKK4 status. RESULTS: Primary tumors (N = 124) were scored as 0 (no labeling), 1+ (weak labeling), or 2+ (strong labeling) in 9 (7%), 80 (65%), and 35 (28%) patients, and 5-year survival in these patients was 0%, 21%, and 28%, respectively. Given the small size (7%) of the MKK4-negative group (as expected, given the 5%-10% incidence of genetic loss in carcinomas), a Cox proportional hazards analysis was performed, adjusting for age, sex, and tumor stage. This multivariate analysis revealed a 5-fold increased risk of death (P<.001) in patients whose primary tumors were MKK4-negative. Furthermore, the addition of MKK4 status significantly improved the Cox model, changing log likelihood from -1410 to -369, confirming that MKK4 status was truly the effector of the survival difference and not a bystander. CONCLUSIONS: The lack of expression of the tumor-suppressor gene MKK4 in resected gastric adenocarcinoma is robustly associated with poor survival. This finding may provide a useful prognostic tool in patients with gastric adenocarcinoma.

MKK4 status predicts survival after resection of gastric adenocarcinoma. Publishing Authors By Initials

SC Cunningham,F Kamangar,MP Kim,S Hammoud,R Haque,C Iacobuzio-Donahue,R Ashfaq,SE Kern,A Maitra,RE Heitmiller,MA Choti,KD Lillemoe,JL Cameron,CJ Yeo,E Montgomery,RD Schulick,

For similar investigative techniques: epidemiologic methods: data collection: vital statistics: mortality: survival rate research abstracts see: investigative techniques: epidemiologic methods: data collection: vital statistics: mortality: survival rate research

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MKK4 status predicts survival after resection of gastric adenocarcinoma. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Archives of surgery (Chicago, Ill. : 1960)

VOLUME: 141

Page Numbers: 1095-9; discussion 1100

Journal Abbreviation:

ISSN: 0004-0010

DAY: 3

MONTH: Nov

YEAR: 2006

MKK4 status predicts survival after resection of gastric adenocarcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9716528

MKK4 status predicts survival after resection of gastric adenocarcinoma. Keywords Mesh Terms:

KEYWORDS: Survival Rate

MESH TERMS: pathology

Chemical & Substance for Abstract: MKK4 status predicts survival after resection of gastric adenocarcinoma. Information

Substance Name: MAP Kinase Kinase 4

Registry Number: EC 2.7.1.-

Grant and Affiliation Information for MKK4 status predicts survival after resection of gastric adenocarcinoma.

AFFILIATION: Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231-1000, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA62924

ACRONYM: CA

MEDLINETA: Arch Surg

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