Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients.

Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients. Abstract Text:

Hiroshi Tanaka,Koji Tsugawa,Eishin Oki,Koichi Suzuki,Etsuro Ito,Hiroshi Tanaka,Koji Tsugawa,Eishin Oki,Koichi Suzuki,Etsuro Ito,Hiroshi Tanaka,Koji Tsugawa,Eishin Oki,Koichi Suzuki,Etsuro Ito,

The objective of the current work is to report our preliminary experience with the mizoribine (MZR) intermittent pulse protocol for induction therapy for newly diagnosed pediatric-onset systemic lupus erythematosus (SLE). Five consecutive patients who were newly diagnosed as having SLE with biopsy-proven lupus nephritis were recruited for an open-label trial of prednisolone (PDN) and MZR intermittent pulse therapy (10 mg/kg for 2 days of the week for 12 months). Data on the renal response and serologic lupus activity were collected prospectively. The baseline characteristics of the patients were: mean age, 11 years; urinary protein/creatinine ratio (U-prot./cre.), 0.99 +/- 0.91; serum complement hemolytic activity (CH50), 10.6 +/- 1.3 (normal, 23-46 U/ml); serum anti-dsDNA antibody titer, 258.6 +/- 125.5 IU/ml (normal, <12.0 IU/ml); serum creatinine, 0.5 +/- 0.1 mg/dl; European Consensus Lupus Activity Measurement index (ECLAM), 7.4 +/- 1.1. The primary endpoint was the interval until the development of a flare of SLE. Despite gradual tapering of the PDN dose, significant improvement as compared to the baseline values was observed in all the parameters examined at 3, 6, and 12 months of treatment. After 12 months therapy, complete response was achieved in all of the patients, except for 1 patient who showed poor drug compliance. In two patients who had severe lupus nephritis at the first renal biopsy, marked histologic improvement was confirmed at the second renal biopsy. No serious adverse effects were observed. We believe that the MZR pulse protocol combined with PDN for induction therapy may be the treatment of choice in selected young patients with SLE. Further studies to confirm the long-term efficacy and safety of our current protocol in larger numbers of patients are, however, needed.

Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients. Publishing Authors By Initials

H Tanaka,K Tsugawa,E Oki,K Suzuki,E Ito,H Tanaka,K Tsugawa,E Oki,K Suzuki,E Ito,H Tanaka,K Tsugawa,E Oki,K Suzuki,E Ito,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical rheumatology

VOLUME: 27

Page Numbers: 85-9

Journal Abbreviation: Clin. Rheumatol.

ISSN: 0770-3198

DAY: 5

MONTH: 05

YEAR: 2007

Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8211469

Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients.

AFFILIATION: Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki, 036-8562, Japan, hirotana@cc.hirosaki-u.ac.jp.

Country: Belgium

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Rheumatol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Mizoribine intermittent pulse protocol for induction therapy for systemic lupus erythematosus in children: an open-label pilot study with five newly diagnosed patients Related Publications

• A molecular phylogeny of the genus Echinococcus inferred from complete mitochondrial genomes.
• A soft X-ray (80-1500 eV) grazing-incidence monochromator with varied-line-spacing plane gratings at PF-BL-11A.
• Activity of anti-Porphyromonas gingivalis egg yolk antibody against gingipains in vitro.
• Bacterial, fungal and yeast contamination in six brands of irreversible hydrocolloid impression materials.
• Biomimetic coating of an apatite layer on poly(L-lactic acid); improvement of adhesive strength of the coating.
• Bone metabolism and formation of mice bred in a 2 G environment.
• Bootstrap significance test of synchronous spike events--a case study of oscillatory spike trains.
• Cervical spine loads and intervertebral motions during whiplash.
• Design of a Holographically Recorded Plane Grating with a Varied Line Spacing for a Soft X-ray Grazing-Incidence Monochromator.
• Editorial comment: factor that influence serum prostate-specific antigen levels in terms of maintaining quality within a PSA screening system.
• Endoglucanases from Paenibacillus spp. form a new clan in glycoside hydrolase family 5.
• Excess tyrosine stimulates eumelanin and pheomelanin synthesis in cultured slaty melanocytes from neonatal mouse epidermis.
• Impairment of endothelium-dependent relaxation of aortas and pulmonary arteries from spontaneously hyperlipidemic mice (Apodemus sylvaticus).
• In vitro antimicrobial activity of different gutta-percha points and calcium hydroxide pastes.
• In vitro antimicrobial activity of endodontic sealers, MTA-based cements and Portland cement.
• Intestinal cestodes.
• Involvement of MCP-1 in tubulointerstitial fibrosis through massive proteinuria in anti-GBM nephritis induced in WKY rats.
• Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water.
• Management of patients with normal-pressure hydrocephalus by using lumboperitoneal shunt system with the Codman Hakim programmable valve.
• Mid-term effects of steroid therapy on childhood-onset IgA nephropathy.
• Numerical Calculations of Heating Patterns around a Coaxial-Slot Antenna for Microwave Hyperthermia - Aiming at Treatment of Brain Tumor and Bile Duct Carcinoma-.
• Protection of estrogens against the progression of chronic liver disease.
• Recent outcome of Graves' disease patients with papillary thyroid cancer.
• Runt-related transcription factor 3 expression in human oral squamous cell carcinomas; implication for tumor progression and prognosis.
• SecY alterations that impair membrane protein folding and generate a membrane stress.
• Self-assembled via axial coordination magnesium porphyrin-imidazole appended fullerene dyad: spectroscopic, electrochemical, computational, and photochemical studies.
• Strain differences in the diabetogenic activity of streptozotocin in mice.
• Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants.
• [Detection of Cysticercus bovis in a calf injected intravenously with taenia saginata hexacanth]
• [Rabies virus in naturally infected bats in the State of São Paulo, Southeastern Brazil]