Mixed serous carcinoma of the endometrium with trophoblastic differentiation: analysis of the p53 tumor suppressor gene suggests stem cell origin.

Mixed serous carcinoma of the endometrium with trophoblastic differentiation: analysis of the p53 tumor suppressor gene suggests stem cell origin. Research Abstract Details 

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Mixed serous carcinoma of the endometrium with trophoblastic differentiation: analysis of the p53 tumor suppressor gene suggests stem cell origin. Abstract Text:

Lars-Christian Horn,Claudia ,Erika Bartholdt,Jochen Dietel,Lars-Christian Horn,Claudia Hänel,Erika Bartholdt,Jochen Dietel,

The pathogenesis of mixed endometrial adenocarcinoma with trophoblastic differentiation is quite unclear at times. The present study examines a serous carcinoma with choriocarcinomatous differentiation. p53 staining was seen in the serous component and the cytotrophoblastic cells of the choriocarcinomatous component, but not in the syncytiotrophoblastic cells. p53 mutational analysis showed a heterozygotic mutation at exon 8 for the choriocarcinomatous component and a homozygote deletion at exon 7 for the serous component. These alterations suggest that the multidirectional tumor differentiation might occur from a common stem cell in these malignancies.

Mixed serous carcinoma of the endometrium with trophoblastic differentiation: analysis of the p53 tumor suppressor gene suggests stem cell origin. Publishing Authors By Initials

LC Horn,C ,E Bartholdt,J Dietel,LC Horn,C Hänel,E Bartholdt,J Dietel,

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Mixed serous carcinoma of the endometrium with trophoblastic differentiation: analysis of the p53 tumor suppressor gene suggests stem cell origin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of diagnostic pathology

VOLUME: 12

Page Numbers: 1-3

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ISSN: 1092-9134

DAY: 29

MONTH: 10

YEAR: 2007

Mixed serous carcinoma of the endometrium with trophoblastic differentiation: analysis of the p53 tumor suppressor gene suggests stem cell origin. Information

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LANGUAGE: eng

NlmUniqueID: 9800503

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Grant and Affiliation Information for Mixed serous carcinoma of the endometrium with trophoblastic differentiation: analysis of the p53 tumor suppressor gene suggests stem cell origin.

AFFILIATION: Institute of Pathology, University of Leipzig, D-04103 Leipzig, Germany; Division of Gynecologic Pathology, University of Leipzig, D-04103 Leipzig, Germany.

Country: United States

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MEDLINETA: Ann Diagn Pathol

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