Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape.

Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape. Research Abstract Details 

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Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape. Abstract Text:

Janet C Effler,Yee-Seir Kee,Jason M Berk,Minhchau N Tran,Pablo A Iglesias,Douglas N Robinson,

Because cell-division failure is deleterious, promoting tumorigenesis in mammals, cells utilize numerous mechanisms to control their cell-cycle progression. Though cell division is considered a well-ordered sequence of biochemical events, cytokinesis, an inherently mechanical process, must also be mechanically controlled to ensure that two equivalent daughter cells are produced with high fidelity. Given that cells respond to their mechanical environment, we hypothesized that cells utilize mechanosensing and mechanical feedback to sense and correct shape asymmetries during cytokinesis. Because the mitotic spindle and myosin II are vital to cell division, we explored their roles in responding to shape perturbations during cell division. We demonstrate that the contractile proteins myosin II and cortexillin I redistribute in response to intrinsic and externally induced shape asymmetries. In early cytokinesis, mechanical load overrides spindle cues and slows cytokinesis progression while contractile proteins accumulate and correct shape asymmetries. In late cytokinesis, mechanical perturbation also directs contractile proteins but without apparently disrupting cytokinesis. Significantly, this response only occurs during anaphase through cytokinesis, does not require microtubules, and is independent of spindle orientation, but is dependent on myosin II. Our data provide evidence for a mechanosensory system that directs contractile proteins to regulate cell shape during mitosis.

Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape. Publishing Authors By Initials

JC Effler,YS Kee,JM Berk,MN Tran,PA Iglesias,DN Robinson,

For similar proteins: protozoan proteins research abstracts see: proteins: protozoan proteins research

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Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Current biology : CB

VOLUME: 16

Page Numbers: 1962-7

Journal Abbreviation: Curr. Biol.

ISSN: 0960-9822

DAY: 10

MONTH: Oct

YEAR: 2006

Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107782

Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape. Keywords Mesh Terms:

KEYWORDS: Protozoan Proteins

MESH TERMS: physiology

Chemical & Substance for Abstract: Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape. Information

Substance Name: Myosin Type II

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Mitosis-specific mechanosensing and contractile-protein redistribution control cell shape.

AFFILIATION: Department of Cell Biology, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, Maryland 21205, USA.

Country: England

AGENCY: United States NIGMS

GRANT: R01 GM066817

ACRONYM: GM

MEDLINETA: Curr Biol

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