Mitochondrial trafficking and morphology in healthy and injured neurons.

Mitochondrial trafficking and morphology in healthy and injured neurons. Research Abstract Details 

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Mitochondrial trafficking and morphology in healthy and injured neurons. Abstract Text:

Diane T W Chang,Ian J Reynolds,

Mitochondria are the primary generators of ATP and are important regulators of intracellular calcium homeostasis. These organelles are dynamically transported along lengthy neuronal processes, presumably for appropriate distribution to cellular regions of high metabolic demand and elevated intracellular calcium, such as synapses. The removal of damaged mitochondria that produce harmful reactive oxygen species and promote apoptosis is also thought to be mediated by transport of mitochondria to autophagosomes. Mitochondrial trafficking is therefore important for maintaining neuronal and mitochondrial health while cessation of movement may lead to neuronal and mitochondrial dysfunction. Mitochondrial morphology is also dynamic and is remodeled during neuronal injury and disease. Recent studies reveal different manifestations and mechanisms of impaired mitochondrial movement and altered morphology in injured neurons. These are likely to cause varied courses toward neuronal degeneration and death. The goal of this review is to provide an appreciation of the full range of mitochondrial function, morphology and trafficking, and the critical role these parameters play in neuronal physiology and pathophysiology.

Mitochondrial trafficking and morphology in healthy and injured neurons. Publishing Authors By Initials

DT Chang,IJ Reynolds,

For similar inorganic chemicals: free radicals: reactive oxygen species research abstracts see: inorganic chemicals: free radicals: reactive oxygen species research

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Mitochondrial trafficking and morphology in healthy and injured neurons. Journal Published:

PUBLICATION TYPE: Review

Journal: Progress in neurobiology

VOLUME: 80

Page Numbers: 241-68

Journal Abbreviation: Prog. Neurobiol.

ISSN: 0301-0082

DAY: 26

MONTH: 12

YEAR: 2006

Mitochondrial trafficking and morphology in healthy and injured neurons. Information

Number of References: 264

LANGUAGE: eng

NlmUniqueID: 370121

Mitochondrial trafficking and morphology in healthy and injured neurons. Keywords Mesh Terms:

KEYWORDS: Reactive Oxygen Species

MESH TERMS: metabolism

Chemical & Substance for Abstract: Mitochondrial trafficking and morphology in healthy and injured neurons. Information

Substance Name: Calcium

Registry Number: 7440-70-2

Grant and Affiliation Information for Mitochondrial trafficking and morphology in healthy and injured neurons.

AFFILIATION: Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Country: England

AGENCY: United States NINDS

GRANT: NS049560

ACRONYM: NS

MEDLINETA: Prog Neurobiol

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