Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase.

Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase. Abstract Text:

Yamin Wang,Usha Singh,David M Mueller,

The mitochondrial ATP synthase is a molecular motor, which couples the flow of protons with phosphorylation of ADP. Rotation of the central stalk within the core of ATP synthase effects conformational changes in the active sites driving the synthesis of ATP. Mitochondrial genome integrity (mgi) mutations have been previously identified in the alpha-, beta-, and gamma-subunits of ATP synthase in yeast Kluyveromyces lactis and trypanosome Trypanosoma brucei. These mutations reverse the lethality of the loss of mitochondrial DNA in petite negative strains. Introduction of the homologous mutations in Saccharomyces cerevisiae results in yeast strains that lose mitochondrial DNA at a high rate and accompanied decreases in the coupling of the ATP synthase. The structure of yeast F1-ATPase reveals that the mgi residues cluster around the gamma-subunit and selectively around the collar region of F1. These results indicate that residues within the mgi complementation group are necessary for efficient coupling of ATP synthase, possibly acting as a support to fix the axis of rotation of the central stalk.

Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase. Publishing Authors By Initials

Y Wang,U Singh,DM Mueller,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research

PUBMED ID PMID:

MEDLINE DATE:

Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 8228-36

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 23

MONTH: 01

YEAR: 2007

Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase. Keywords Mesh Terms:

KEYWORDS: Sequence Homology, Amino Acid

MESH TERMS: genetics

Chemical & Substance for Abstract: Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase. Information

Substance Name: Proton-Translocating ATPases

Registry Number: EC 3.6.3.14

Grant and Affiliation Information for Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase.

AFFILIATION: Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01-GM067091

ACRONYM: GM

MEDLINETA: J Biol Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase Related Publications

• A case report of Clarkson's disease: If you don't know it, you'll miss it.
• Algorithms for on-line Differentiation of Neuroelectric Activities.
• Allopeptide-specific CD4(+) T cells facilitate the differentiation of directly alloreactive graft-infiltrating CD8(+) T Cells.
• An open trial of levetiracetam for segmental and generalized dystonia.
• Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis.
• Dosage in the treatment of pollinosis.
• Effect of footwear and orthotic devices on stress reduction and soft tissue strain of the neuropathic foot.
• Exercise training and sympathetic nervous system activity: evidence for physical activity dependent neural plasticity.
• Exercise training attenuates increases in lumbar sympathetic nerve activity produced by stimulation of the rostral ventrolateral medulla.
• Lattice-based volumetric global illumination.
• Low sex hormone-binding globulin as a predictive marker for insulin resistance in women with hyperandrogenic syndrome.
• Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase.
• Molecular recognition of BMP-2 and BMP receptor IA.
• Non-catalytic function for ATR in the checkpoint response.
• Novel features of the rotary catalytic mechanism revealed in the structure of yeast F1 ATPase.
• Numerical simulation of the plantar pressure distribution in the diabetic foot during the push-off stance.
• Oleamide synthesizing activity from rat kidney: identification as cytochrome c.
• On the hemolytic and thrombogenic potential of occluder prosthetic heart valves from in-vitro measurements.
• Pioglitazone: an anti-diabetic compound with anti-aging properties.
• Real-time 3D computed tomographic reconstruction using commodity graphics hardware.
• TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases.
• The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae.
• The amide rotational barrier in isonicotinamide: Dynamic NMR and ab initio studies.
• The experience of rural independent pharmacies with medicare part D: reports from the field.
• The risk of malarial infections and disease in Papua New Guinean children.
• The use of B-type natriuretic peptides in the intensive care unit.
• Trace element removal during in vitro and in vivo continuous haemodialysis.
• Transcriptional dysregulation during myeloid transformation in AML.
• Vaccines against malaria - an update.
• Virus infection causes specific learning deficits in honeybee foragers.