Mitochondrial genetic polymorphisms and pancreatic cancer risk.

Mitochondrial genetic polymorphisms and pancreatic cancer risk. Research Abstract Details 

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Mitochondrial genetic polymorphisms and pancreatic cancer risk. Abstract Text:

Liang Wang,William R Bamlet,Mariza de Andrade,Lisa A Boardman,Julie M Cunningham,Stephen N Thibodeau,Gloria M Petersen,

The role of genes that influence the risk of developing pancreatic cancer (PC) has not been well studied. The mitochondrion, conventionally thought to be an organelle specific to energy metabolism, is in fact multifunctional and has been implicated in many diseases, including cancer. To evaluate whether single nucleotide polymorphisms in mitochondrial DNA (mtSNP) are associated with increased risk of PC, we screened Caucasian cases diagnosed or seen at the Mayo Clinic with primary pancreatic adenocarcinoma (n = 955), and healthy clinic-based Caucasian controls (n = 1,102). A total of 24 mtSNPs, including 10 of the most common tagSNPs, 7 non-tagSNPs in the coding region, and 7 common SNPs in the regulatory region were genotyped. For analysis, these samples were grouped into two phases, the "testing" set (474 cases and 615 controls), and the "validation" set (481 cases and 487 controls). In the testing set, one mtSNP (SNP11719) suggested an association in single SNP analysis, with an odds ratio of 1.34 (95% confidence intervals, 1.05-1.72; P = 0.020), but did not remain statistically significant after correction for multiple testing. In the validation set, none of the 24 variants indicated any association with PC. For haplogroup analysis, 10 core SNPs that form common haplogroups in Caucasians (1719, 4580, 7028, 8251, 9055, 10398, 12308, 13368, 13708, and 16391) were evaluated. No significant associations with PC were identified either by analyzing the two sets separately or combined (combined global P = 0.17). Overall, these results do not support a significant involvement of mitochondrial DNA variation in the risk of developing PC. Investigation of other mitochondrial genetic variations (i.e., nuclear-encoded mitochondrial proteins) would be necessary to elucidate any role of mitochondrial DNA variation in PC.

Mitochondrial genetic polymorphisms and pancreatic cancer risk. Publishing Authors By Initials

L Wang,WR Bamlet,M de Andrade,LA Boardman,JM Cunningham,SN Thibodeau,GM Petersen,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Mitochondrial genetic polymorphisms and pancreatic cancer risk. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 16

Page Numbers: 1455-9

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 3

MONTH: Jul

YEAR: 2007

Mitochondrial genetic polymorphisms and pancreatic cancer risk. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9200608

Mitochondrial genetic polymorphisms and pancreatic cancer risk. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Mitochondrial genetic polymorphisms and pancreatic cancer risk. Information

Substance Name: Genetic Markers

Registry Number: 0

Grant and Affiliation Information for Mitochondrial genetic polymorphisms and pancreatic cancer risk.

AFFILIATION: Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Stabile 241, Rochester, MN 55905, USA. wang.liang@mayo.edu

Country: United States

AGENCY: United States NCI

GRANT: P50 CA102701

ACRONYM: CA

MEDLINETA: Cancer Epidemiol Biomarkers Pr

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