Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review.

Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review. Research Abstract Details 

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Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review. Abstract Text:

Grace J Kim,Krish Chandrasekaran,William F Morgan,

Radiation-induced genomic instability (RIGI) challenges the long-standing notion that radiation's effects derive solely from nuclear impact. In RIGI it is the unirradiated progeny that can display phenotypic changes at delayed times after irradiation of the parental cell. RIGI might well provide the driving force behind the development of radiation-induced tumorigenesis as most cancer cells even in pre-neoplastic states display multiple genetic alterations. Thus, understanding RIGI may help elucidate the mechanisms underlying radiation-induced carcinogenesis. One characteristic of clones of genetically unstable cells is that many exhibit persistently increased levels of reactive oxygen species (ROS). Furthermore, oxidants enhance and antioxidants diminish radiation-induced instability. However, much about the mechanisms behind the initiation and perpetuation of RIGI remains unknown and we examine the evidence for the hypothesis that oxidative stress and mitochondrial dysfunction may be involved in perpetuating the unstable phenotype in some cell clones surviving ionizing radiation.

Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review. Publishing Authors By Initials

GJ Kim,K Chandrasekaran,WF Morgan,

For similar inorganic chemicals: free radicals: reactive oxygen species research abstracts see: inorganic chemicals: free radicals: reactive oxygen species research

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Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review. Journal Published:

PUBLICATION TYPE: Review

Journal: Mutagenesis

VOLUME: 21

Page Numbers: 361-7

Journal Abbreviation: Mutagenesis

ISSN: 0267-8357

DAY: 25

MONTH: 10

YEAR: 2006

Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review. Information

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LANGUAGE: eng

NlmUniqueID: 8707812

Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review. Keywords Mesh Terms:

KEYWORDS: Reactive Oxygen Species

MESH TERMS: metabolism

Chemical & Substance for Abstract: Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review. Information

Substance Name: Reactive Oxygen Species

Registry Number: 0

Grant and Affiliation Information for Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review.

AFFILIATION: Radiation Oncology Research Laboratory, University of Maryland-Baltimore, 108 North Greene Street, BRF Room 110C, Baltimore, MD 21201, USA. gkim002@umaryland.edu

Country: England

AGENCY: United States NCI

GRANT: CA 83872

ACRONYM: CA

MEDLINETA: Mutagenesis

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