Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice.

Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice. Abstract Text:

Jie Xu,Chun Shi,Qi Li,Jiajia Wu,E Lucy Forster,David T Yew,Jie Xu,Chun Shi,Qi Li,Jiajia Wu,E Lucy Forster,David T Yew,

Senescence-accelerated mice (SAM) strains are useful models to understand the mechanisms of age-dependent degeneration. In this study, measurements of the mitochondrial membrane potential (Deltapsi(m)) of platelets and the Adenosine 5(')-triphosphate (ATP) content of hippocampi and platelets were made, and platelet mitochondria were observed in SAMP8 (faster aging mice) and SAMR1 (aging resistant control mice) at 2, 6 and 9 months of age. In addition, an Abeta-induced (Amyloid beta-protein) damage model of platelets was established. After the addition of Abeta, the Deltapsi(m) of platelets of SAMP8 at 1 and 6 months of age were measured. We found that platelet Deltapsi(m), and hippocampal and platelet ATP content of SAMP8 mice decreased at a relatively early age compared with SAMR1. The platelets of 6 month-old SAMP8 showed a tolerance to Abeta-induced damages. These results suggest that mitochondrial dysfunction might be one of the mechanisms leading to age-associated degeneration in SAMP mice at an early age and the platelets could serve as a biomarker for detection of mitochondrial function and age related disease.

Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice. Publishing Authors By Initials

J Xu,C Shi,Q Li,J Wu,EL Forster,DT Yew,J Xu,C Shi,Q Li,J Wu,EL Forster,DT Yew,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of bioenergetics and biomembranes

VOLUME: 39

Page Numbers: 195-202

Journal Abbreviation: J. Bioenerg. Biomembr.

ISSN: 0145-479X

DAY: 14

MONTH: 04

YEAR: 2007

Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7701859

Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice.

AFFILIATION: Department of Anatomy, Zhongshan School of Medicine, Sun Yat-Sen University Guangzhou, Guangdong 510080, China.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Bioenerg Biomembr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice Related Publications

• Bacteria detection utilizing electrical conductivity.
• Can the Interferon-{gamma} Release Assay Help Diagnose Active Tuberculosis in the Elderly?
• Cardiovascular adverse effects during itraconazole therapy.
• Cell death in the Purkinje cells of the cerebellum of senescence accelerated mouse (SAMP(8)).
• Decline in prevalence of latent tuberculosis infection: is the waning of tuberculin reaction a factor?
• Diagnosis of chronic obstructive pulmonary disease.
• Effects of Buyang Huanwu Decoction on neurite outgrowth and differentiation of neuroepithelial stem cells.
• Effects of beta-amyloid peptide and estrogen on platelet mitochondrial function of Sprague-Dawley rats.
• Effects of genistein on hippocampal neurodegeneration of ovariectomized rats.
• Evidence of DNA Transfer through F-pilus Channels during Escherichia coli Conjugation.
• Fibreoptic bronchoscopy in the diagnosis of lung cancer.
• H2O2-induced changes in astrocytic cultures from control and rapidly aging strains of mouse.
• Microscopic analysis of the different regions of three Alzheimer brains aged 93, 94, and 104 years old.
• Mitochondrial dysfunction in platelets and hippocampi of senescence-accelerated mice.
• Performance parameters for focusing of radial polarization.
• Perinatal hypoxia induces anterior chamber changes in the eyes of offspring fish.
• Perinatal hypoxia induces subsequent retinal degeneration in the offspring of ovoviviparous fish, Xiphophorous maculates.
• Postmortem MRI changes of the brains of the rats of different ages.
• Screening contacts of tuberculosis: overcoming obstacles with an old tool.
• Study of the spinal cords of the sturgeon Acipenser schrenckii, gar Lepisosteus oculatus, and goldfish Carassius auratus by morphological, immunohistochemical, and biochemical approaches.
• Study on twins: a good tool for infectious diseases?
• Time-course expression of vascular endothelial growth factor as related to the development of the retinochoroidal vasculature in rats.
• alpha-Crystallin Protected Axons from Optic Nerve Degeneration After Crushing in Rats.