Mitochondrial content of choroid plexus epithelium.

Mitochondrial content of choroid plexus epithelium. Research Abstract Details 

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Mitochondrial content of choroid plexus epithelium. Abstract Text:

E M Cornford,J B Varesi,S Hyman,R T Damian,M J Raleigh,

The objective of the present study was to examine the apparent work capacity of one of the two separate membrane systems (the blood-cerebrospinal fluid barrier) that isolate the mammalian brain extracellular fluid (and cerebrospinal fluid, CSF) from plasma. Digitized analyses of electron-microscopic images provided estimates of mitochondrial volumes, which were expressed as a percentage of the cell cytoplasm. We recorded a high mitochondrial content of 12-15% in the cuboidal epithelium of primate choroid plexus, which was consistent in vervet, rhesus, and squirrel monkeys, as well as in baboons. Similarly high mitochondrial contents were observed in the rabbit, rat, and mouse choroid plexus. It has been postulated that the high mitochondrial content of brain endothelium is associated with maintaining the ionic gradients within the central nervous system. We observed that the mitochondrial content of the choroid plexus (where CSF is produced) was slightly higher than in (prior measurements of) the blood-brain barrier (BBB). In addition, surface areas at the apical borders of the choroid plexus epithelia (where the Na+K+ATPase activity has been localized) were increased 7- to 13-fold over the basal borders, in the primate species examined. The observation of high mitochondrial volumes in choroid plexus cells is consistent with the suggestion that increased mitochondrial densities seen in choroidal epithelia and BBB capillaries provide a metabolic work capability for both secretory activities and maintaining ionic gradients across blood-CSF barriers.

Mitochondrial content of choroid plexus epithelium. Publishing Authors By Initials

EM Cornford,JB Varesi,S Hyman,RT Damian,MJ Raleigh,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Mitochondrial content of choroid plexus epithelium. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 116

Page Numbers: 399-405

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: Oct

YEAR: 1997

Mitochondrial content of choroid plexus epithelium. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Mitochondrial content of choroid plexus epithelium. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: anatomy & histology

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Grant and Affiliation Information for Mitochondrial content of choroid plexus epithelium.

AFFILIATION: Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA.

Country: GERMANY

AGENCY: United States NINDS

GRANT: NS 25554

ACRONYM: NS

MEDLINETA: Exp Brain Res

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