Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria.

Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria. Research Abstract Details 

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Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria. Abstract Text:

T Omura,

The intracellular sorting of newly synthesized precursor proteins (preproteins) to mitochondria depends on the "mitochondria-targeting sequence" (MTS), which is located at the amino termini of the preproteins. MTS is required, however, not only for targeting newly synthesized preproteins to mitochondria, but also for all the following steps along the mitochondrial protein import pathway. MTS of nascent preproteins is first recognized by a cytoplasmic molecular chaperone, MSF, and then by Tom70 and Tom20 of the mitochondrial outer membrane receptor complex, Tom5 and Tom40 of the outer membrane protein translocation machinery, Tim23 of the inner membrane protein translocation machinery, and finally the processing peptidase, MPP, in the matrix. MTS is a multi-role sorting sequence which specifically interacts with various components along the mitochondrial protein import pathway. Recognition of MTS at multiple steps during the import of preproteins may contribute to the strict sorting of proteins destined for mitochondria.

Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria. Publishing Authors By Initials

T Omura,

For similar investigative techniques: genetic techniques: sequence analysis research abstracts see: investigative techniques: genetic techniques: sequence analysis research

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Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of biochemistry

VOLUME: 123

Page Numbers: 1010-6

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jun

YEAR: 1998

Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria. Information

Number of References: 66

LANGUAGE: eng

NlmUniqueID: 376600

Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria. Keywords Mesh Terms:

KEYWORDS: Sequence Analysis

MESH TERMS: metabolism

Chemical & Substance for Abstract: Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria. Information

Substance Name: mitochondrial import stimulation factor,

Registry Number: 158027-98-6

Grant and Affiliation Information for Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria.

AFFILIATION: Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Fukuoka, 812-8582, Japan. omurat@mxs.meshnet.or.jp

Country: JAPAN

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MEDLINETA: J Biochem

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