Mitochondria, cell death, and B cell tolerance.

Mitochondria, cell death, and B cell tolerance. Research Abstract Details 

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Mitochondria, cell death, and B cell tolerance. Abstract Text:

To prevent autoimmunity, it is critical that tolerance mechanisms block autoantibody production from self-reactive B cells. B cell tolerance is maintained through mechanisms that can reversibly or irreversibly silence autoreactive B cells. Of these mechanisms, those that lead to B cell death offer the most reliable form of tolerance to prevent autoimmunity. In many cases, death of autoreactive B cells is regulated by the cell intrinsic, or mitochondrial pathway of cell death. The pro-apoptotic Bcl-2 family proteins, Bak, Bax, and Bim have been shown to be required for disruption of mitochondria and intrinsic cell death of self-reactive B cells whereas the anti-apoptotic Bcl-2, Bcl-xL, and Mcl-1 can prevent cell death by interfering with the action of Bax and Bak. Bcl-2 and Bcl-xL have also been shown to regulate the autophagic cell death pathway that may also play a role in B cell tolerance. Even after mitochondrial disruption, mechanisms exist that may impede activation of caspases and death of autoreactive B cells. Together, understanding of cell death mechanisms and how they may affect B cell tolerance has made significant recent advances and it is now important to incorporate alternate and post-mitochondrial cell death mechanisms into B cell tolerance models.

Mitochondria, cell death, and B cell tolerance. Publishing Authors By Initials

For similar peptides: intracellular signaling peptides and proteins: apoptosis regulatory proteins: proto-oncogene proteins c-bcl-2: bcl-2-associated x protein research abstracts see: peptides: intracellular signaling peptides and proteins: apoptosis regulatory proteins: proto-oncogene proteins c-bcl-2: bcl-2-associated x protein research

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Mitochondria, cell death, and B cell tolerance. Journal Published:

PUBLICATION TYPE: Review

Journal: Current directions in autoimmunity

VOLUME: 9

Page Numbers: 95-119

Journal Abbreviation: Curr. Dir. Autoimmun.

ISSN: 1422-2132

DAY: 14

MONTH: 05

YEAR: 2006

Mitochondria, cell death, and B cell tolerance. Information

Number of References: 168

LANGUAGE: eng

NlmUniqueID: 101121763

Mitochondria, cell death, and B cell tolerance. Keywords Mesh Terms:

KEYWORDS: bcl-2-Associated X Protein

MESH TERMS: physiology

Chemical & Substance for Abstract: Mitochondria, cell death, and B cell tolerance. Information

Substance Name: Cyclic AMP-Dependent Protein Kinases

Registry Number: EC 2.7.11.11

Grant and Affiliation Information for Mitochondria, cell death, and B cell tolerance.

AFFILIATION: Department of Pathology and Vermont Cancer Center, University of Vermont, Burlington, Vt., USA.

Country: Switzerland

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MEDLINETA: Curr Dir Autoimmun

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