MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion.

MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion. Research Abstract Details 

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MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion. Abstract Text:

Yuma Yamada,Hidetaka Akita,Hiroyuki Kamiya,Kentaro Kogure,Takenori Yamamoto,Yasuo Shinohara,Kikuji Yamashita,Hideo Kobayashi,Hiroshi Kikuchi,Hideyoshi Harashima,Yuma Yamada,Hidetaka Akita,Hiroyuki Kamiya,Kentaro Kogure,Takenori Yamamoto,Yasuo Shinohara,Kikuji Yamashita,Hideo Kobayashi,Hiroshi Kikuchi,Hideyoshi Harashima,

Mitochondria are the principal producers of energy in higher cells. Mitochondrial dysfunction is implicated in a variety of human diseases, including cancer and neurodegenerative disorders. Effective medical therapies for such diseases will ultimately require targeted delivery of therapeutic proteins or nucleic acids to the mitochondria, which will be achieved through innovations in the nanotechnology of intracellular trafficking. Here we describe a liposome-based carrier that delivers its macromolecular cargo to the mitochondrial interior via membrane fusion. These liposome particles, which we call MITO-Porters, carry octaarginine surface modifications to stimulate their entry into cells as intact vesicles (via macropinocytosis). We identified lipid compositions for the MITO-Porter which promote both its fusion with the mitochondrial membrane and the release of its cargo to the intra-mitochondrial compartment in living cells. Thus, the MITO-Porter holds promise as an efficacious system for the delivery of both large and small therapeutic molecules into mitochondria.

MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion. Publishing Authors By Initials

Y Yamada,H Akita,H Kamiya,K Kogure,T Yamamoto,Y Shinohara,K Yamashita,H Kobayashi,H Kikuchi,H Harashima,Y Yamada,H Akita,H Kamiya,K Kogure,T Yamamoto,Y Shinohara,K Yamashita,H Kobayashi,H Kikuchi,H Harashima,

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MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochimica et biophysica acta

VOLUME: 1778

Page Numbers: 423-32

Journal Abbreviation: Biochim. Biophys. Acta

ISSN: 0006-3002

DAY: 12

MONTH: 11

YEAR: 2007

MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion. Information

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LANGUAGE: eng

NlmUniqueID: 217513

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AFFILIATION: Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.

Country: Netherlands

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MEDLINETA: Biochim Biophys Acta

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