Misoprostol associated refractile material in fetal and placental tissues after medical termination of pregnancy.

Misoprostol associated refractile material in fetal and placental tissues after medical termination of pregnancy. Research Abstract Details 

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Misoprostol associated refractile material in fetal and placental tissues after medical termination of pregnancy. Abstract Text:

Vincent Ho,Sarah Keating,John Kingdom,Patrick Shannon,Vincent Ho,Sarah Keating,John Kingdom,Patrick Shannon,

Misoprostol is a synthetic prostaglandin analog administered vaginally to induce labor for intrauterine death or termination of pregnancy for congenital abnormalities. We encountered a case of misoprostol induction of labor at 14 weeks of gestation for fetal acrania associated with amniotic bands. Histology demonstrated abundant deposits of refractile material appearing to be of vegetable fiber origin on the maternal surface of the fetal membranes. Misoprostol tablet scrapings had a similar microscopic appearance. Ten additional placentas from cases of misoprostol induction of labor between 16 and 18 weeks of gestation were examined and half were found to contain such deposits. No deposits were seen in cases between 15 and 18 weeks of gestation where misoprostol was not used. We attribute the refractile material to a nonmedicinal ingredient, microcrystalline cellulose, in the misoprostol tablet preparation. This study demonstrates that vaginal administration of misoprostol tablets can be detected microscopically in at least half of cases and may have a florid appearance simulating a potential causative factor of fetal malformation. Despite the large amounts of microcrystalline cellulose and its apparent embedding in placental tissue, the misoprostol in our index case was unlikely to have caused the amniotic bands and the resulting cranial abnormality.

Misoprostol associated refractile material in fetal and placental tissues after medical termination of pregnancy. Publishing Authors By Initials

V Ho,S Keating,J Kingdom,P Shannon,V Ho,S Keating,J Kingdom,P Shannon,

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Misoprostol associated refractile material in fetal and placental tissues after medical termination of pregnancy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The American journal of surgical pathology

VOLUME: 31

Page Numbers: 1893-6

Journal Abbreviation: Am. J. Surg. Pathol.

ISSN: 0147-5185

DAY: 28

MONTH: Dec

YEAR: 2007

Misoprostol associated refractile material in fetal and placental tissues after medical termination of pregnancy. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Misoprostol associated refractile material in fetal and placental tissues after medical termination of pregnancy.

AFFILIATION: Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

Country: United States

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MEDLINETA: Am J Surg Pathol

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