miRNA: the new gene silencer.

miRNA: the new gene silencer. Research Abstract Details 

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miRNA: the new gene silencer. Abstract Text:

Jeffrey S Ross,J Andrew Carlson,Graham Brock,

MicroRNAs (miRNAs) can be defined as small, noncoding sets of 19 to 24 nucleotides that have been associated with messenger RNA expression. miRNAs are members of a class of small regulatory RNAs that includes small interfering RNAs (siRNAs). miRNAs regulate the expression of downstream gene targets, including transcription factors, oncogenes, and tumor suppressor genes. Transcriptional profiling using genomic microarrays and beads has enabled the discovery of numerous miRNAs that are differentially expressed in normal tissues vs tumors and associated with cancer development, diagnosis, and prognosis. miRNA signatures can be used to detect and classify cancer and predict the severity of disease, with certain profiles of miRNA expression linked to aggressive cancers with advanced disease present at diagnosis. miRNAs have also become targets of novel anticancer gene therapy with antisense molecules that can inhibit miRNA activity currently being tested for their efficacy in a strategy of reducing miRNA activity on reporter genes bearing miRNA-binding sites. In the future, sophisticated genomic and proteomic techniques combined with complex bioinformatics data analyses will be required to translate these recent basic science discoveries to clinically useful diagnostic tests.

miRNA: the new gene silencer. Publishing Authors By Initials

JS Ross,JA Carlson,G Brock,

For similar nucleic acids, nucleotides, and nucleosides: antisense elements (genetics): rna, antisense: rna, small interfering research abstracts see: nucleic acids, nucleotides, and nucleosides: antisense elements (genetics): rna, antisense: rna, small interfering research

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miRNA: the new gene silencer. Journal Published:

PUBLICATION TYPE: Review

Journal: American journal of clinical pathology

VOLUME: 128

Page Numbers: 830-6

Journal Abbreviation: Am. J. Clin. Pathol.

ISSN: 0002-9173

DAY: 29

MONTH: Nov

YEAR: 2007

miRNA: the new gene silencer. Information

Number of References: 50

LANGUAGE: eng

NlmUniqueID: 370470

miRNA: the new gene silencer. Keywords Mesh Terms:

KEYWORDS: RNA, Small Interfering

MESH TERMS: genetics

Chemical & Substance for Abstract: miRNA: the new gene silencer. Information

Substance Name: RNA, Small Interfering

Registry Number: 0

Grant and Affiliation Information for miRNA: the new gene silencer.

AFFILIATION: Department of Pathology and Laboratory Medicine, Albany Medical College, NY 12208, USA.

Country: United States

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MEDLINETA: Am J Clin Pathol

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