Minireview: estrogen receptor-mediated rapid signaling.

Minireview: estrogen receptor-mediated rapid signaling. Research Abstract Details 

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Minireview: estrogen receptor-mediated rapid signaling. Abstract Text:

K Moriarty,K H Kim,J R Bender,

In addition to nuclear-initiated (genomic) responses, estrogen receptors (ERs) have the ability to facilitate rapid, membrane-initiated, estrogen-triggered signaling cascades via a plasma membrane-associated form of the receptor. These rapid responses are dependent on assembly of membrane ER-centered multimolecular complexes, which can transduce ligand-activated signals to affect a variety of enzymatic pathways, often occurring in a cell-type-specific fashion with tissue-specific physiological outcomes. In some instances, cross-talk occurs between these membrane-initiated and nuclear responses, ultimately regulating transcriptional activation. The role of splice variants in membrane-initiated estrogen responses has been described, notably those within the vascular endothelium. In this review, we describe the evidence for membrane ERs, the molecular components of the aforementioned signaling complexes and pathways, the relevance of ER splice variants, and ER-mediated responses in specific tissues. Our growing understanding of ER-mediated actions at a molecular level will provide insight into the controversies surrounding hormone replacement therapy in postmenopausal women.

Minireview: estrogen receptor-mediated rapid signaling. Publishing Authors By Initials

K Moriarty,KH Kim,JR Bender,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Minireview: estrogen receptor-mediated rapid signaling. Journal Published:

PUBLICATION TYPE: Review

Journal: Endocrinology

VOLUME: 147

Page Numbers: 5557-63

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 31

MONTH: 08

YEAR: 2006

Minireview: estrogen receptor-mediated rapid signaling. Information

Number of References: 76

LANGUAGE: eng

NlmUniqueID: 375040

Minireview: estrogen receptor-mediated rapid signaling. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Minireview: estrogen receptor-mediated rapid signaling. Information

Substance Name: Receptors, Estrogen

Registry Number: 0

Grant and Affiliation Information for Minireview: estrogen receptor-mediated rapid signaling.

AFFILIATION: Sections of Cardiovascular Medicine and Immunobiology, Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA.

Country: United States

AGENCY: United States PHS

GRANT: T3207950

ACRONYM: HL

MEDLINETA: Endocrinology

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