Mining OMIM for insight into complex diseases.

Mining OMIM for insight into complex diseases. Research Abstract Details 

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Mining OMIM for insight into complex diseases. Abstract Text:

Understanding clinical phenotypes through their corresponding genotypes is one of the principal goals of genetic research. Though achieving this goal is relatively simple with single gene syndromes, more complex diseases often consist of varied clinical phenotypes that may be the result of interactions among multiple genetic loci. Microarray technology has brought the phenotype -genotype relationship to the molecular level, using differently behaving cancers, for example, as the basis for comparing patterns of gene expression. With this feasibility study, we attempted to use similar methods of analysis at the clinical level, in order to evaluate our hypothesis that the clustering of clinical phenotypes would provide information that would be useful in elucidating their underlying genotypes. Because of its breadth of content and detailed descriptions, we used OMIM as our source material for phenotypic and genetic information. After processing the source material, we then performed self-organizing map and hierarchical clustering analysis on representative diseases by phenotypic category. Through pre-determined queries over this analysis, we made two findings of potential clinical significance, one concerning diabetes and another concerning progressive neurologic diseases. Our methods provide a formal approach to analyzing phenotypes among diverse diseases, and may help indicate fruitful areas for further research into their underlying genetic causes.

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Mining OMIM for insight into complex diseases. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Studies in health technology and informatics

VOLUME: 107

Page Numbers: 753-7

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ISSN: 0926-9630

DAY: 10

MONTH: 07

YEAR: 2004

Mining OMIM for insight into complex diseases. Information

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LANGUAGE: eng

NlmUniqueID: 9214582

Mining OMIM for insight into complex diseases. Keywords Mesh Terms:

KEYWORDS: Phenotype

MESH TERMS: genetics

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Grant and Affiliation Information for Mining OMIM for insight into complex diseases.

AFFILIATION: Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA.

Country: Netherlands

AGENCY: United States NLM

GRANT: LM-07079

ACRONYM: LM

MEDLINETA: Stud Health Technol Inform

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