Mimicry of antimicrobial host-defense peptides by random copolymers.

Mimicry of antimicrobial host-defense peptides by random copolymers. Research Abstract Details 

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Mimicry of antimicrobial host-defense peptides by random copolymers. Abstract Text:

Brendan P Mowery,Sarah E Lee,Denis A Kissounko,Raquel F Epand,Richard M Epand,Bernard Weisblum,Shannon S Stahl,Samuel H Gellman,Brendan P Mowery,Sarah E Lee,Denis A Kissounko,Raquel F Epand,Richard M Epand,Bernard Weisblum,Shannon S Stahl,Samuel H Gellman,Brendan P Mowery,Sarah E Lee,Denis A Kissounko,Raquel F Epand,Richard M Epand,Bernard Weisblum,Shannon S Stahl,Samuel H Gellman,

Efforts to generate antibacterial agents via mimicry of host-defense peptides have focused on discrete oligomers that can adopt a regular globally amphiphilic conformation in the presence of bacterial cell membranes and ultimately disrupt those membranes. Although considerable success has been achieved with this approach, application of the resulting molecules is hampered by the high cost associated with stepwise oligomer synthesis. We show that random poly-beta-peptide copolymers, prepared by ring-opening polymerization of beta-lactams, can be tuned to display good activity against a panel of four bacteria along with low lytic activity toward human red blood cells. These findings support a nonclassical design hypothesis for antibacterial agents.

Mimicry of antimicrobial host-defense peptides by random copolymers. Publishing Authors By Initials

BP Mowery,SE Lee,DA Kissounko,RF Epand,RM Epand,B Weisblum,SS Stahl,SH Gellman,BP Mowery,SE Lee,DA Kissounko,RF Epand,RM Epand,B Weisblum,SS Stahl,SH Gellman,BP Mowery,SE Lee,DA Kissounko,RF Epand,RM Epand,B Weisblum,SS Stahl,SH Gellman,

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Mimicry of antimicrobial host-defense peptides by random copolymers. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the American Chemical Society

VOLUME: 129

Page Numbers: 15474-6

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 1520-5126

DAY: 23

MONTH: 11

YEAR: 2007

Mimicry of antimicrobial host-defense peptides by random copolymers. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Mimicry of antimicrobial host-defense peptides by random copolymers.

AFFILIATION: Department of Chemistry and Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, and Department of Biochemistry and Biomedical Sciences, McMaster University Health Sciences Centre, Hamilton, Ontario L8N 3Z5, Canada.

Country: United States

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MEDLINETA: J Am Chem Soc

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