Mimetics of the tri- and tetrasaccharide epitope of GQ1balpha as myelin-associated glycoprotein (MAG) ligands.

Mimetics of the tri- and tetrasaccharide epitope of GQ1balpha as myelin-associated glycoprotein (MAG) ligands. Research Abstract Details 

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Mimetics of the tri- and tetrasaccharide epitope of GQ1balpha as myelin-associated glycoprotein (MAG) ligands. Abstract Text:

Ganpan Gao,Martin Smiesko,Oliver Schwardt,Heiko ,Soerge Kelm,Angelo Vedani,Beat Ernst,Ganpan Gao,Martin Smiesko,Oliver Schwardt,Heiko ,Soerge Kelm,Angelo Vedani,Beat Ernst,Ganpan Gao,Martin Smiesko,Oliver Schwardt,Heiko ,Soerge Kelm,Angelo Vedani,Beat Ernst,

The synthesis of phenoxyphenyl, phenoxybenzyl, biphenyl, and phenyltriazole substituted sialic acid derivatives as mimics of the tri- and tetrasaccharide epitopes of GQ1balpha is described. These synthetically easily available sialosides show comparable or even enhanced affinity to MAG compared with the natural tri- and tetrasaccharide epitopes and form a new class of potential MAG antagonists.

Mimetics of the tri- and tetrasaccharide epitope of GQ1balpha as myelin-associated glycoprotein (MAG) ligands. Publishing Authors By Initials

G Gao,M Smiesko,O Schwardt,H ,S Kelm,A Vedani,B Ernst,G Gao,M Smiesko,O Schwardt,H ,S Kelm,A Vedani,B Ernst,G Gao,M Smiesko,O Schwardt,H ,S Kelm,A Vedani,B Ernst,

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Mimetics of the tri- and tetrasaccharide epitope of GQ1balpha as myelin-associated glycoprotein (MAG) ligands. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry

VOLUME: 15

Page Numbers: 7459-69

Journal Abbreviation: Bioorg. Med. Chem.

ISSN: 0968-0896

DAY: 21

MONTH: 08

YEAR: 2007

Mimetics of the tri- and tetrasaccharide epitope of GQ1balpha as myelin-associated glycoprotein (MAG) ligands. Information

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LANGUAGE: eng

NlmUniqueID: 9413298

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Grant and Affiliation Information for Mimetics of the tri- and tetrasaccharide epitope of GQ1balpha as myelin-associated glycoprotein (MAG) ligands.

AFFILIATION: Institute of Molecular Pharmacy, Pharmacenter, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.

Country: England

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MEDLINETA: Bioorg Med Chem

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