Mild radioiodination of insulin with dichloramine-T.

Mild radioiodination of insulin with dichloramine-T. Research Abstract Details 

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Mild radioiodination of insulin with dichloramine-T. Abstract Text:

T Jyotsna,M R Pillai,J H Gupte,R S Mani,

Iodination of insulin using N-dichloro-p-toluene sulphonamide(dichloramine-T) has been standardised. Dichloramine-T, a water insoluble derivative of chloramine-T showed excellent properties as an iodination reagent, for the preparation of radiolabeled insulin for use in radioimmunoassay. Iodination using dichloramine-T could be done at as low as 0.5-2 micrograms of the reagent, and at this concentration the molar ratio worked out to 1:3 to 1:12 (protein:dichloramine-T). Iodination yields of greater than 90% were obtained at pH 5-7. Evaluation of the iodinated tracer for suitability in radioimmunoassay was carried out by estimating radiochemical purity, immunological purity, non specific binding and stability on storage.

Mild radioiodination of insulin with dichloramine-T. Publishing Authors By Initials

T Jyotsna,MR Pillai,JH Gupte,RS Mani,

For similar organic chemicals: amides: sulfonamides research abstracts see: organic chemicals: amides: sulfonamides research

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Mild radioiodination of insulin with dichloramine-T. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of radiation applications an

VOLUME: 13

Page Numbers: 549-50

Journal Abbreviation:

ISSN: 0883-2897

DAY: 21

MONTH: 02

YEAR: 1986

Mild radioiodination of insulin with dichloramine-T. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8611098

Mild radioiodination of insulin with dichloramine-T. Keywords Mesh Terms:

KEYWORDS: Sulfonamides

MESH TERMS: methods

Chemical & Substance for Abstract: Mild radioiodination of insulin with dichloramine-T. Information

Substance Name: dichloramine-T

Registry Number: 473-34-7

Grant and Affiliation Information for Mild radioiodination of insulin with dichloramine-T.

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Country: UNITED STATES

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MEDLINETA: Int J Rad Appl Instrum B

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