Mild chronic hypoxia modifies the fetal sheep neural and cardiovascular responses to repeated umbilical cord occlusion.

Mild chronic hypoxia modifies the fetal sheep neural and cardiovascular responses to repeated umbilical cord occlusion. Research Abstract Details 

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Mild chronic hypoxia modifies the fetal sheep neural and cardiovascular responses to repeated umbilical cord occlusion. Abstract Text:

Victor M Pulgar,Jie Zhang,G Angela Massmann,Jorge P Figueroa,

We have shown that 5 days of mild hypoxia has significant effects on fetal ECoG activity, heart rate and blood pressure. We now studied if mild prolonged hypoxemia had an adverse effect on the fetal cardiovascular and neural responses to repeated cord occlusion and on the magnitude of neuronal damage. Fetal and maternal catheters were placed at 120 days' gestation and animals allocated at random to receive intratracheal maternal administration of nitrogen (n=8) or compressed air in controls (n=7). Five days after surgery, nitrogen infusion was adjusted to reduce fetal brachial artery pO(2) by 25%. After 5 days of chronic hypoxemia, the umbilical cord was completely occluded for 5 min every 30 min for a total of four occlusions. Data are presented as mean+/-SEM and were analyzed by two-way ANOVA or two-sample t-test. Nitrogen infusion decreased fetal pO(2) by 26% (20.5+/-1.7 vs. 14.3+/-0.8 mm Hg) without changing fetal pCO(2) or pH. Pre-existing hypoxia fetuses had a greater terminal fall in heart rate in occlusions II, III and IV, and also had a more severe terminal hypotension in the final occlusion. Pre-existing hypoxia was associated with a greater fall in spectral edge frequency during occlussions from 14.4+/-0.9 Hz to 6.9+/-0.4 Hz vs. 13.6+/-1.64 Hz to 10.6+/-0.77 Hz in controls, p<0.05. In addition, during the three-day post-occlusion period, the contribution of theta and alpha band frequencies to total ECoG activity was significantly lower in the pre-existing hypoxia fetuses (p<0.05). These effects were associated with increased neuronal loss in the striatum (p<0.05). In summary, the cardiovascular and neural response indicates a detrimental effect of pre-existing mild hypoxia on fetal outcome following repeated umbilical cord occlusions.

Mild chronic hypoxia modifies the fetal sheep neural and cardiovascular responses to repeated umbilical cord occlusion. Publishing Authors By Initials

VM Pulgar,J Zhang,GA Massmann,JP Figueroa,

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Mild chronic hypoxia modifies the fetal sheep neural and cardiovascular responses to repeated umbilical cord occlusion. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Brain research

VOLUME: 1176

Page Numbers: 18-26

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 22

MONTH: 08

YEAR: 2007

Mild chronic hypoxia modifies the fetal sheep neural and cardiovascular responses to repeated umbilical cord occlusion. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Mild chronic hypoxia modifies the fetal sheep neural and cardiovascular responses to repeated umbilical cord occlusion.

AFFILIATION: Perinatal Research Laboratory, Department of Obstetrics and Gynecology, Center for Research in Obstetrics and Gynecology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

Country: Netherlands

AGENCY: United States NICHD

GRANT: R01 HD038964-05

ACRONYM: HD

MEDLINETA: Brain Res

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