Midkine enhances early stages of collagen gel contraction.

Midkine enhances early stages of collagen gel contraction. Research Abstract Details 

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Midkine enhances early stages of collagen gel contraction. Abstract Text:

Y Sumi,H Muramatsu,K Hata,M Ueda,T Muramatsu,

Midkine (MK) is a heparin-binding growth/differentiation factor implicated in the control of development and repair of various tissues. To investigate the roles of MK in embryogenesis and in regulation of wound healing, we utilized a system of collagen gel contraction by dermal fibroblasts, which provides an in vitro model for studying fibroblast-collagen interactions important in various physiological and pathological phenomena. MK enhanced gel contraction 8-24 h after plating, and its effect was inhibited by anti-MK antibody. The effect was reduced after 48 h, while TGF-beta continued to be active in the later stage. Morphologically, MK-treated fibroblasts tended to be elongated more frequently than control fibroblasts. The effect of MK in the early stage of gel contraction suggests a role of MK as a modulator of cell-matrix interactions.

Midkine enhances early stages of collagen gel contraction. Publishing Authors By Initials

Y Sumi,H Muramatsu,K Hata,M Ueda,T Muramatsu,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Midkine enhances early stages of collagen gel contraction. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 127

Page Numbers: 247-51

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Feb

YEAR: 2000

Midkine enhances early stages of collagen gel contraction. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Midkine enhances early stages of collagen gel contraction. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: metabolism

Chemical & Substance for Abstract: Midkine enhances early stages of collagen gel contraction. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Midkine enhances early stages of collagen gel contraction.

AFFILIATION: Department of Biochemistry and Department of Oral and Maxillofacial Surgery, Nagoya University School of Medicine, Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

Country: JAPAN

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MEDLINETA: J Biochem

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