Midkine counteracts the activin signal in mesoderm induction and promotes neural formation.

Midkine counteracts the activin signal in mesoderm induction and promotes neural formation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Midkine counteracts the activin signal in mesoderm induction and promotes neural formation. Abstract Text:

C Yokota,S Takahashi,A Eisaki,M Asashima,S Akhter,T Muramatsu,K Kadomatsu,

Midkine (MK) is a heparin-binding growth factor that has been implicated in neural survival and differentiation, fibrinolysis, and carcinogenesis. It is expressed in the nervous system during early Xenopus development. In the present study, we demonstrated that injection of vegetal blastomeres with Xenopus MK at the 8-cell stage results in incomplete invagination. In the case of dorsal vegetal injection, hypertrophic neural tissue is produced. Animal caps isolated from embryos that have been injected with Xenopus MK and cultured with activin do not elongate, and all mesoderm markers examined, including both head and trunk/tail ones, are greatly diminished. In contrast, head-specific neural markers, XANF-1 and Xotx2, are induced, while trunk/tail neural markers, XlHbox6 and F-spondin, are decreased. Moreover, MK showes the same effects in animal caps injected with Xenopus Smad2 mRNA.

Midkine counteracts the activin signal in mesoderm induction and promotes neural formation. Publishing Authors By Initials

C Yokota,S Takahashi,A Eisaki,M Asashima,S Akhter,T Muramatsu,K Kadomatsu,

For similar animals: chordata: vertebrates: amphibia: anura: pipidae: xenopus: xenopus laevis research abstracts see: animals: chordata: vertebrates: amphibia: anura: pipidae: xenopus: xenopus laevis research

PUBMED ID PMID:

MEDLINE DATE:

Midkine counteracts the activin signal in mesoderm induction and promotes neural formation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 123

Page Numbers: 339-46

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Feb

YEAR: 1998

Midkine counteracts the activin signal in mesoderm induction and promotes neural formation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Midkine counteracts the activin signal in mesoderm induction and promotes neural formation. Keywords Mesh Terms:

KEYWORDS: Xenopus laevis

MESH TERMS: physiology

Chemical & Substance for Abstract: Midkine counteracts the activin signal in mesoderm induction and promotes neural formation. Information

Substance Name: Inhibins

Registry Number: 57285-09-3

Grant and Affiliation Information for Midkine counteracts the activin signal in mesoderm induction and promotes neural formation.

AFFILIATION: Department of Biology, The University of Tokyo.

Country: JAPAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Midkine counteracts the activin signal in mesoderm induction and promotes neural formation Related Publications

• Downregulation of Monocyte Chemoattractant Protein-1 Involving Short Interfering RNA Attenuates Hapten-induced Contact Hypersensitivity.
• In vivo silencing of a molecular target by short interfering RNA electroporation: tumor vascularization correlates to delivery efficiency.
• Marionette traction for Le Fort I maxillary halo distraction in cleft patients.
• Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells.
• Midkine counteracts the activin signal in mesoderm induction and promotes neural formation.
• Midkine is expressed by infiltrating macrophages in in-stent restenosis in hypercholesterolemic rabbits.
• Midkine rescues Wilms' tumor cells from cisplatin-induced apoptosis: regulation of Bcl-2 expression by Midkine.
• Restricted expression of Xenopus midkine gene during early development.