[Microvessel density and endothelial area in assessment of angiogenesis in patients with laryngeal cancer]

[Microvessel density and endothelial area in assessment of angiogenesis in patients with laryngeal cancer] Research Abstract Details 

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[Microvessel density and endothelial area in assessment of angiogenesis in patients with laryngeal cancer] Abstract Text:

Wioletta Pietruszewska, Kobos,Maciej Gryczy?ski,

The growth of solid tumours and the process of metastasis are dependent on the formation of new blood vessels. Indeed, the intensity of angiogenesis has been shown to be increase in various human tumours. The main aim of this work was the assessment of angiogenesis intensity (AI) in patients with laryngeal cancer using two methods: microvessels density (MVD) and microvessels area (MVA). The group of 151 patients with laryngeal cancer, surgically treated with minimum 5 years observation, was multi-variously analysed. Paraffin--embedded tissue sections from each case were stained with a monoclonal antibody raised against FVIII and CD34 antigens. Intensity of angiogenesis (IA) was measured as microvessels density (MVD) and microvessels area (MVA) by mean of computer image analysis. There were statistically significant correlation between IA measured as MVD using CD34 and tumour size and nodal metastasis. IA described as MVA correlated with: staging, tumour size, nodal recurrences and metastasis. IA measured as MVD after using anti-FVIII correlated with tumour size and nodal metastasis. MVA correlated with staging and nodal recurrences. Overall survival was related to IA measured as MVD using anti-CD34 and anti-FVIII. Disease-free survival was related to IA measured as MVD using anti-VIII. Intensity of angiogenesis has prognostic value in patients with laryngeal cancer. Both methods: microvessels density and microvessels area seems to have similar value in assessment of angiogenesis intensity.

[Microvessel density and endothelial area in assessment of angiogenesis in patients with laryngeal cancer] Publishing Authors By Initials

W Pietruszewska,J Kobos,M Gryczy?ski,

For similar diagnosis: prognosis research abstracts see: diagnosis: prognosis research

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[Microvessel density and endothelial area in assessment of angiogenesis in patients with laryngeal cancer] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Otolaryngologia polska. The Polish otolaryngology

VOLUME: 57

Page Numbers: 5-15

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ISSN: 0030-6657

DAY: 28

MONTH: 12

YEAR: 2003

[Microvessel density and endothelial area in assessment of angiogenesis in patients with laryngeal cancer] Information

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LANGUAGE: pol

NlmUniqueID: 404453

[Microvessel density and endothelial area in assessment of angiogenesis in patients with laryngeal cancer] Keywords Mesh Terms:

KEYWORDS: Prognosis

MESH TERMS: pathology

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Grant and Affiliation Information for [Microvessel density and endothelial area in assessment of angiogenesis in patients with laryngeal cancer]

AFFILIATION: Katedra Otolaryngologii i Klinika Laryngologii AM w ?odzi.

Country: Poland

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MEDLINETA: Otolaryngol Pol

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