Microvascular injury in lymphomatoid granulomatosis involving the skin. An ultrastructural study.

Microvascular injury in lymphomatoid granulomatosis involving the skin. An ultrastructural study. Research Abstract Details 

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Microvascular injury in lymphomatoid granulomatosis involving the skin. An ultrastructural study. Abstract Text:

An electron microscopic study of a cutaneous lesion of lymphomatoid granulomatosis taken from a patient with pulmonary involvement was performed. Microvascular alterations ranged from mild, degenerative changes to vessel necrosis. Less severe changes included enlarged endothelial cells, with margination of small lymphoid cells in affected vessels. Luminal occlusion by necrotic endothelial cell fragments and fibrin was associated with thickening and reduplication of the basal lamina and an angiocentric, inflammatory infiltrate in severely affected vessels. The most frequently observed cells in the infiltrate were cleaved and noncleaved lymphocytes that exhibited notable cytolysis and degenerative changes in cytoplasmic organelles. We conclude that lymphomatoid granulomatosis involving the skin is a disorder in which substantial numbers of cleaved and noncleaved lymphoid cells participate, eventuating in small-vessel necrosis and occlusion and repeated endothelial cell regeneration.

Microvascular injury in lymphomatoid granulomatosis involving the skin. An ultrastructural study. Publishing Authors By Initials

For similar neoplasms: neoplasms by site: skin neoplasms research abstracts see: neoplasms: neoplasms by site: skin neoplasms research

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Microvascular injury in lymphomatoid granulomatosis involving the skin. An ultrastructural study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of dermatology

VOLUME: 117

Page Numbers: 804-8

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Dec

YEAR: 1981

Microvascular injury in lymphomatoid granulomatosis involving the skin. An ultrastructural study. Information

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LANGUAGE: eng

NlmUniqueID: 372433

Microvascular injury in lymphomatoid granulomatosis involving the skin. An ultrastructural study. Keywords Mesh Terms:

KEYWORDS: Skin Neoplasms

MESH TERMS: ultrastructure

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Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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