Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens.

Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens. Research Abstract Details 

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Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens. Abstract Text:

Tia K Smith,Bernard Choi,Julio C Ramirez-San-Juan,J Stuart Nelson,Kathryn Osann,Kristen M Kelly,

BACKGROUND AND OBJECTIVES: Previous in vitro studies demonstrated the potential utility of benzoporphyrin derivative monoacid ring A (BPD) photodynamic therapy (PDT) for vascular destruction. Moreover, the effects of PDT were enhanced when this intervention was followed immediately by pulsed dye laser (PDL) irradiation (PDT/PDL). We further evaluate vascular effects of PDT alone, PDL alone and PDT/PDL in an in vivo rodent dorsal skinfold model. STUDY DESIGN/MATERIALS AND METHODS: A dorsal skinfold window chamber was installed surgically on female Sprague-Dawley rats. One milligram per kilogram of BPD solution was administered intravenously via a jugular venous catheter. Evaluated interventions were: control (no BPD, no light), PDT alone (576 nm, 16 minutes exposure time, 15 minutes post-BPD injection, 10 mm spot), PDL alone at 7 J/cm2 (585 nm, 1.5 ms pulse duration, 7 mm spot), PDL alone at 10 J/cm2, PDT/PDL (PDL at 7 J/cm2), and PDT/PDL (PDL at 10 J/cm2). To assess changes in microvascular blood flow, laser speckle imaging was performed before, immediately after, and 18 hours post-intervention. RESULTS: Epidermal irradiation was accomplished without blistering, scabbing or ulceration. A reduction in perfusion was achieved in all intervention groups. PDT/PDL at 7 J/cm2 resulted in the greatest reduction in vascular perfusion (56%). CONCLUSIONS: BPD PDT can achieve safe and selective vascular flow reduction. PDT/PDL can enhance diminution of microvascular blood flow. Our results suggest that PDT and PDT/PDL should be evaluated as alternative therapeutic options for treatment of hypervascular skin lesions including port wine stain birthmarks.

Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens. Publishing Authors By Initials

TK Smith,B Choi,JC Ramirez-San-Juan,JS Nelson,K Osann,KM Kelly,

For similar integumentary system: skin research abstracts see: integumentary system: skin research

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Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Lasers in surgery and medicine

VOLUME: 38

Page Numbers: 532-9

Journal Abbreviation:

ISSN: 0196-8092

DAY: 3

MONTH: Jun

YEAR: 2006

Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8007168

Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens. Keywords Mesh Terms:

KEYWORDS: Skin

MESH TERMS: blood supply

Chemical & Substance for Abstract: Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens. Information

Substance Name: verteporfin

Registry Number: 129497-78-5

Grant and Affiliation Information for Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens.

AFFILIATION: Beckman Laser Institute, University of California, Irvine, California 92612, USA.

Country: United States

AGENCY: United States NIBIB

GRANT: EB002495

ACRONYM: EB

MEDLINETA: Lasers Surg Med

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