Microstructural white matter changes in primary torsion dystonia.

Microstructural white matter changes in primary torsion dystonia. Research Abstract Details 

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Microstructural white matter changes in primary torsion dystonia. Abstract Text:

Maren Carbon,Peter B Kingsley,Chengke Tang,Susan Bressman,David Eidelberg,

Primary torsion dystonia (PTD) has been conceptualized as a disorder of the basal ganglia. However, recent data suggest a widespread pathology involving motor control pathways. In this report, we explored whether PTD is associated with abnormal anatomical connectivity within motor control pathways. We used diffusion tensor magnetic resonance imaging (DT-MRI) to assess the microstructure of white matter. We found that fractional anisotropy, a measure of axonal integrity and coherence, was significantly reduced in PTD patients in the pontine brainstem in the vicinity of the left superior cerebellar peduncle and bilaterally in the white matter of the sensorimotor region. Our data thus support the possibility of a disturbance in cerebello-thalamo-cortical pathways as a cause of the clinical manifestations of PTD. (c) 2007 Movement Disorder Society.

Microstructural white matter changes in primary torsion dystonia. Publishing Authors By Initials

M Carbon,PB Kingsley,C Tang,S Bressman,D Eidelberg,

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Microstructural white matter changes in primary torsion dystonia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Movement disorders : official journal of the Movem

VOLUME: 23

Page Numbers: 234-9

Journal Abbreviation: Mov. Disord.

ISSN: 0885-3185

DAY: 30

MONTH: Jan

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 8610688

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AFFILIATION: Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York.

Country: United States

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MEDLINETA: Mov Disord

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