Microsatellite instability in long-standing ulcerative colitis.

Microsatellite instability in long-standing ulcerative colitis. Research Abstract Details 

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Microsatellite instability in long-standing ulcerative colitis. Abstract Text:

Tone ,Solveig Norheim Andersen,Ole Petter Clausen,Torleiv Ole Rognum,

OBJECTIVE: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon associated with a high risk of developing colorectal cancer. Several genetic alterations have been documented in dysplasia and cancer developing in UC. Concerning microsatellite instability (MSI), many contradictory results have been published. We therefore analysed a large, well-characterized UC material for MSI to elucidate its significance in long-standing UC. MATERIAL AND METHODS: From 33 patients, a total of 159 microdissected lesions and 165 mucosa samples obtained adjacent to the tissue blocks were analysed for MSI using the five standard markers recommended by the National Cancer Institute; D2S123, D5S346, D17S250, BAT-25 and BAT-26. In addition, 12 of the patients were investigated by a mini-satellite marker at the D1S7 locus. RESULTS: High-level MSI (MSI-H) was detected in one villous adenoma with high-grade dysplasia and right-sided location. This represents 3.6% (1/28) of dysplastic mucosa investigated. No other lesions showed MSI in the five standard markers or at the D1S7 locus. CONCLUSIONS: This study suggests that MSI is rare in UC-related neoplasia as well as non-neoplastic lesions, and does not contribute to the development of dysplasia.

Microsatellite instability in long-standing ulcerative colitis. Publishing Authors By Initials

T ,SN Andersen,OP Clausen,TO Rognum,

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Microsatellite instability in long-standing ulcerative colitis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Scandinavian journal of gastroenterology

VOLUME: 42

Page Numbers: 586-91

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ISSN: 0036-5521

DAY: 24

MONTH: May

YEAR: 2007

Microsatellite instability in long-standing ulcerative colitis. Information

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LANGUAGE: eng

NlmUniqueID: 60105

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Grant and Affiliation Information for Microsatellite instability in long-standing ulcerative colitis.

AFFILIATION: Institute of Forensic Medicine, Department of Pathology, Akershus University Hospital HF, Lørenskog, Norway. tone.lovig@labmed.uio.no

Country: Norway

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MEDLINETA: Scand J Gastroenterol

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