Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type.

Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type. Abstract Text:

Israel Zighelboim,Paul J Goodfellow,Feng Gao,Randall K Gibb,Matthew A Powell,Janet S Rader,David G Mutch,

PURPOSE: Most studies of microsatellite instability (MSI) and outcomes in endometrial cancer patients have included varied histologic subtypes. Nonetheless, MSI occurs almost exclusively in endometrioid tumors. The impact of MSI on outcomes in patients with endometrial cancer is controversial. We sought to determine whether MSI and MLH1 methylation are associated with clinicopathologic variables and survival outcomes in a large series of patients with endometrial carcinomas of the endometrioid type. PATIENTS AND METHODS: Tumor samples, blood, and clinicopathologic data were prospectively collected and analyzed for 446 patients with endometrioid carcinomas. MSI was determined using five National Cancer Institute (NCI) consensus panel markers, and the methylation status of the MLH1 promoter was determined by combined bisulfite restriction analysis (COBRA). Associations with clinicopathologic variables and survival outcomes were evaluated. RESULTS: MSI was identified in 147 cases (33%). MSI was associated with higher International Federation of Gynecology and Obstetrics (FIGO) grade (P < .0001). MSI+ tumors without MLH1 methylation were associated with younger age (P < .001). MSI was not associated with overall survival (OS; hazard ratio [HR], 1.011; 95% CI, 0.688 to 1.484; P = .96) or disease-free survival (DFS; HR 0.951; 95% CI, 0.554 to 1.635; P = .86). The combined MSI/MLH1 methylation status (treating MSI- as the reference) did not predict OS (MSI+/MLH1-U: HR, 0.62; 95% CI, 0.27 to 1.44; P = .26; MSI+/MLH1-M: HR, 0.95; 95% CI, 0.62 to 1.46; P = .82) or DFS (MSI+/MLH1-U: HR, 0.51; 95% CI, 0.22 to 1.19; P = .12; MSI+/MLH1-M: HR, 0.93; 95% CI, 0.62 to 1.40; P = .72). CONCLUSION: MSI is not associated with survival in patients with endometrioid endometrial cancer.

Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type. Publishing Authors By Initials

I Zighelboim,PJ Goodfellow,F Gao,RK Gibb,MA Powell,JS Rader,DG Mutch,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research

PUBMED ID PMID:

MEDLINE DATE:

Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of clinical oncology : official journal of

VOLUME: 25

Page Numbers: 2042-8

Journal Abbreviation: J. Clin. Oncol.

ISSN: 1527-7755

DAY: 20

MONTH: May

YEAR: 2007

Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8309333

Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type. Keywords Mesh Terms:

KEYWORDS: Prospective Studies

MESH TERMS: genetics

Chemical & Substance for Abstract: Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type. Information

Substance Name: MutS Homolog 2 Protein

Registry Number: EC 3.6.1.3

Grant and Affiliation Information for Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type.

AFFILIATION: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA. zighelboimi@wustl.edu

Country: United States

AGENCY: United States NCI

GRANT: R01 CA71754

ACRONYM: CA

MEDLINETA: J Clin Oncol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type Related Publications

• A multi-institutional evaluation of factors predictive of toxicity and efficacy of bevacizumab for recurrent ovarian cancer.
• Antipeptic and antacid therapy with special reference to adsorbent complexes of calcium and magnesium phosphates.
• Commentary on the revised versions of the definition and classification of cerebral palsy.
• DESCRIPTION OF A NEW PROPTOMETER.
• Drugs in the Treatment of Rheumatic Disorders.
• Drugs used in ophthalmology.
• EFFECTS OF ORAL DIURETICS ON RAISED ARTERIAL PRESSURE.
• FOVILLE'S SYNDROME-RECORD OF A CASE.
• HEREDITARY CORNEAL DYSTROPHY.
• Mental health promotion and non-profit health organisations.
• Metastatic seeding of a percutaneous nephrostomy tract causing cervical carcinoma.
• Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type.
• Molecular profiling and risk stratification of adenocarcinoma of the colon.
• Photorecovery of nanoparticles from an organic solvent.
• Physiological noise versus white noise to drive a variable ventilator in a porcine model of lung injury: [Bruit physiologique versus bruit blanc pour entrainer un respirateur en mode variable dans un modele porcin de lesion pulmonaire].
• THE LACRIMATION REFLEX.
• THE LAURENCE-MOON-BIEDL SYNDROME-RECORD OF A CASE.