MicroRNAs: Biogenesis and Molecular Functions.

MicroRNAs: Biogenesis and Molecular Functions. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

MicroRNAs: Biogenesis and Molecular Functions. Abstract Text:

Xuhang Liu,Kristine Fortin,Zissimos Mourelatos,Xuhang Liu,Kristine Fortin,Zissimos Mourelatos,

Small regulatory RNAs are essential and ubiquitous riboregulators that are the key mediators of RNA interference (RNAi). They include microRNAs (miRNAs) and short-interfering RNAs (siRNAs), classes of approximately 22 nucleotide RNAs. miRNAs and siRNAs bind to Argonaute proteins and form effector complexes that regulate gene expression; in animals, this regulation occurs primarily at the post-transcriptional level. In this review, we will discuss our current understanding of how miRNA and siRNAs are generated and how they function to silence gene expression, focusing on animal and, in particular, mammalian miRNAs.

MicroRNAs: Biogenesis and Molecular Functions. Publishing Authors By Initials

X Liu,K Fortin,Z Mourelatos,X Liu,K Fortin,Z Mourelatos,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

MicroRNAs: Biogenesis and Molecular Functions. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Brain pathology (Zurich, Switzerland)

VOLUME: 18

Page Numbers: 113-21

Journal Abbreviation: Brain Pathol.

ISSN: 1015-6305

DAY: 29

MONTH: Jan

YEAR: 2008

MicroRNAs: Biogenesis and Molecular Functions. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9216781

MicroRNAs: Biogenesis and Molecular Functions. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: MicroRNAs: Biogenesis and Molecular Functions. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for MicroRNAs: Biogenesis and Molecular Functions.

AFFILIATION: Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

Country: Switzerland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Brain Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

MicroRNAs: Biogenesis and Molecular Functions Related Publications

• 2'-O-methyl modification in mouse piRNAs and its methylase.
• A novel monoclonal antibody against human Argonaute proteins reveals unexpected characteristics of miRNAs in human blood cells.
• An mRNA m7G cap binding-like motif within human Ago2 represses translation.
• Introduction and historical background.
• MicroRNAs: Biogenesis and Molecular Functions.
• Site-specific crosslinking of human microRNPs to RNA targets.
• Small RNAs: The seeds of silence.
• Small regulatory RNAs: biogenesis & functions.
• The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs.