MicroRNA regulation of cyclooxygenase-2 during embryo implantation.

MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Research Abstract Details 

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MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Abstract Text:

Anindita Chakrabarty,Susanne Tranguch,Takiko Daikoku,Kevin Jensen,Henry Furneaux,Sudhansu K Dey,

The implantation process is complex, requiring reciprocal interactions between implantation-competent blastocysts and the receptive uterus. Because microRNAs (miRNAs) have major roles in regulating gene expression, we speculated that they participate in directing the highly regulated spatiotemporally expressed genetic network during implantation. Here, we show that two miRNAs, mmu-miR-101a and mmu-miR-199a*, are spatiotemporally expressed in the mouse uterus during implantation coincident with expression of cyclooxygenase-2, a gene critical for implantation. More interestingly, our in vitro gain- and loss-of-function experiments show that cyclooxygenase-2 expression is posttranscriptionally regulated by these two miRNAs. We report on miRNA-mediated regulation of uterine gene expression in the context of implantation. We believe that many other critical genes related to this process are also regulated by miRNAs. Thus, elucidating the physiological roles of uterine miRNAs will help us better understand the genetic control of implantation, the gateway to a successful pregnancy.

MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Publishing Authors By Initials

A Chakrabarty,S Tranguch,T Daikoku,K Jensen,H Furneaux,SK Dey,

For similar urogenital system: genitalia: genitalia, female: uterus research abstracts see: urogenital system: genitalia: genitalia, female: uterus research

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MEDLINE DATE:

MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 15144-9

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 11

MONTH: 09

YEAR: 2007

MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Keywords Mesh Terms:

KEYWORDS: Uterus

MESH TERMS: metabolism

Chemical & Substance for Abstract: MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Information

Substance Name: Cyclooxygenase 2

Registry Number: EC 1.14.99.1

Grant and Affiliation Information for MicroRNA regulation of cyclooxygenase-2 during embryo implantation.

AFFILIATION: Department of Pediatrics, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA.

Country: United States

AGENCY: United States NICHD

GRANT: R37 HD12304

ACRONYM: HD

MEDLINETA: Proc Natl Acad Sci U S A

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