microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder.

microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Research Abstract Details 

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microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Abstract Text:

Diana O Perkins,Clark D Jeffries,L Fredrik Jarskog,J Michael Thomson,Keith Woods,Martin A Newman,Joel S Parker,Jianping Jin,Scott M Hammond,

BACKGROUND: microRNAs (miRNAs) are small, noncoding RNA molecules that are now thought to regulate the expression of many mRNAs. They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile x syndrome, and several types of cancer. RESULTS: We hypothesized that schizophrenia might be associated with altered miRNA profiles. To investigate this possibility we compared the expression of 264 human miRNAs from postmortem prefrontal cortex tissue of individuals with schizophrenia (n = 13) or schizoaffective disorder (n = 2) to tissue of 21 psychiatrically unaffected individuals using a custom miRNA microarray. Allowing a 5% false discovery rate, we found that 16 miRNAs were differentially expressed in prefrontal cortex of patient subjects, with 15 expressed at lower levels (fold change 0.63 to 0.89) and 1 at a higher level (fold change 1.77) than in the psychiatrically unaffected comparison subjects. The expression levels of 12 selected miRNAs were also determined by quantitative RT-PCR in our lab. For the eight miRNAs distinguished by being expressed at lower microarray levels in schizophrenia samples versus comparison samples, seven were also expressed at lower levels with quantitative RT-PCR. CONCLUSION: This study is the first to find altered miRNA profiles in postmortem prefrontal cortex from schizophrenia patients.

microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Publishing Authors By Initials

DO Perkins,CD Jeffries,LF Jarskog,JM Thomson,K Woods,MA Newman,JS Parker,J Jin,SM Hammond,

For similar mental disorders: schizophrenia and disorders with psychotic features: schizophrenia research abstracts see: mental disorders: schizophrenia and disorders with psychotic features: schizophrenia research

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microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genome biology

VOLUME: 8

Page Numbers: R27

Journal Abbreviation:

ISSN: 1465-6914

DAY: 3

MONTH: 12

YEAR: 2007

microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Information

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LANGUAGE: eng

NlmUniqueID: 100960660

microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Keywords Mesh Terms:

KEYWORDS: Schizophrenia

MESH TERMS: metabolism

Chemical & Substance for Abstract: microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Information

Substance Name: MicroRNAs

Registry Number: 0

Grant and Affiliation Information for microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder.

AFFILIATION: Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA. diana_perkins@med.unc.edu

Country: England

AGENCY: United States NIMH

GRANT: R24 MH068855

ACRONYM: MH

MEDLINETA: Genome Biol

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