MicroRNA-133 controls cardiac hypertrophy.

MicroRNA-133 controls cardiac hypertrophy. Research Abstract Details 

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MicroRNA-133 controls cardiac hypertrophy. Abstract Text:

Growing evidence indicates that microRNAs (miRNAs or miRs) are involved in basic cell functions and oncogenesis. Here we report that miR-133 has a critical role in determining cardiomyocyte hypertrophy. We observed decreased expression of both miR-133 and miR-1, which belong to the same transcriptional unit, in mouse and human models of cardiac hypertrophy. In vitro overexpression of miR-133 or miR-1 inhibited cardiac hypertrophy. In contrast, suppression of miR-133 by 'decoy' sequences induced hypertrophy, which was more pronounced than that after stimulation with conventional inducers of hypertrophy. In vivo inhibition of miR-133 by a single infusion of an antagomir caused marked and sustained cardiac hypertrophy. We identified specific targets of miR-133: RhoA, a GDP-GTP exchange protein regulating cardiac hypertrophy; Cdc42, a signal transduction kinase implicated in hypertrophy; and Nelf-A/WHSC2, a nuclear factor involved in cardiogenesis. Our data show that miR-133, and possibly miR-1, are key regulators of cardiac hypertrophy, suggesting their therapeutic application in heart disease.

MicroRNA-133 controls cardiac hypertrophy. Publishing Authors By Initials

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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MicroRNA-133 controls cardiac hypertrophy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature medicine

VOLUME: 13

Page Numbers: 613-8

Journal Abbreviation:

ISSN: 1078-8956

DAY: 29

MONTH: 04

YEAR: 2007

MicroRNA-133 controls cardiac hypertrophy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502015

MicroRNA-133 controls cardiac hypertrophy. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: genetics

Chemical & Substance for Abstract: MicroRNA-133 controls cardiac hypertrophy. Information

Substance Name: Oncogene Protein v-akt

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for MicroRNA-133 controls cardiac hypertrophy.

AFFILIATION: Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanità, 00161 Rome, Italy.

Country: United States

AGENCY: United States PHS

GRANT: HLO65484

ACRONYM: HL

MEDLINETA: Nat Med

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