Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying test.

Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying test. Research Abstract Details 

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Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying test. Abstract Text:

Gabor Legradi,Mahasweta Das,Brian Giunta,Khemraj Hirani,E Alice Mitchell,David M Diamond,Gabor Legradi,Mahasweta Das,Brian Giunta,Khemraj Hirani,E Alice Mitchell,David M Diamond,

High concentrations of pituitary adenylate cyclase-activating polypeptide (PACAP) nerve fibers are present in the central nucleus of amygdala (CeA), a brain region implicated in the control of fear-related behavior. This study evaluated PACAPergic modulation of fear responses at the CeA in male Sprague-Dawley rats. PACAP (50-100 pmol) microinfusion via intra-CeA cannulae produced increases in immobility and time the rats spent withdrawn into a corner opposite to the electrified probe compared to controls in the shock-probe fear/defensive burying test. Shock-probe burying and exploration, numbers of shocks received, locomotion distance, and velocity were all reduced by intra-CeA PACAP injection. Further, intra-CeA PACAP effects were manifested only when the animals were challenged by shock, as intra-CeA PACAP injections did not cause significant changes in the behaviors of unshocked rats. Thus, intra-CeA administration of PACAP produces a distinct reorganization of stress-coping behaviors from active (burying) to passive modes, such as withdrawal and immobility. These findings are potentially significant toward enhancing our understanding of the involvement of PACAP and the CeA in the neural basis of fear and anxiety.

Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying test. Publishing Authors By Initials

G Legradi,M Das,B Giunta,K Hirani,EA Mitchell,DM Diamond,G Legradi,M Das,B Giunta,K Hirani,EA Mitchell,DM Diamond,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying test. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neural plasticity

VOLUME:

Page Numbers: 79102

Journal Abbreviation: Neural Plast.

ISSN: 1687-5443

DAY: 3

MONTH: 12

YEAR: 2007

Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying test. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100883417

Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying test. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying test. Information

Substance Name: Pituitary Adenylate Cyclase-Activating P

Registry Number: 0

Grant and Affiliation Information for Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying test.

AFFILIATION: Department of Pathology and Cell Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA. glegradi@health.usf.edu

Country: United States

AGENCY: United States NIMH

GRANT: R21MH063934

ACRONYM: MH

MEDLINETA: Neural Plast

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