Microinfusion into the rat brain of antibodies against Semliki Forest Virus produces changes in behavioral response to apomorphine.

Microinfusion into the rat brain of antibodies against Semliki Forest Virus produces changes in behavioral response to apomorphine. Research Abstract Details 

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Microinfusion into the rat brain of antibodies against Semliki Forest Virus produces changes in behavioral response to apomorphine. Abstract Text:

Paul M Knopf,Christine J Harling-Berg,Darrin J Lee,Joseph J Hallett,Edward G Stopa,Foroozan Mokhtarian,

Anti-SFV antibodies generated during SFV infection may affect CNS function due to cross-reactivity with a peptide of oligodendrocyte myelin glycoprotein. To explore this possibility, total IgG from SFV immunized or normal control rabbits was unilaterally microinfused into the subthalamic region of normal rat brain. Behavior of the IgG-infused rats was determined using a bioassay, measuring rotational locomotion following systemic injection of apomorphine. Anti-SFV IgG-infused rats demonstrated a significantly increased (p<0.005) ipsilateral turning response compared to control rats, persisting for at least a month. Results suggest that brain cross-reactive antibodies in anti-SFV IgG may affect brain function.

Microinfusion into the rat brain of antibodies against Semliki Forest Virus produces changes in behavioral response to apomorphine. Publishing Authors By Initials

PM Knopf,CJ Harling-Berg,DJ Lee,JJ Hallett,EG Stopa,F Mokhtarian,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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Microinfusion into the rat brain of antibodies against Semliki Forest Virus produces changes in behavioral response to apomorphine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neuroimmunology

VOLUME: 184

Page Numbers: 149-55

Journal Abbreviation: J. Neuroimmunol.

ISSN: 0165-5728

DAY: 25

MONTH: 01

YEAR: 2007

Microinfusion into the rat brain of antibodies against Semliki Forest Virus produces changes in behavioral response to apomorphine. Information

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LANGUAGE: eng

NlmUniqueID: 8109498

Microinfusion into the rat brain of antibodies against Semliki Forest Virus produces changes in behavioral response to apomorphine. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: immunology

Chemical & Substance for Abstract: Microinfusion into the rat brain of antibodies against Semliki Forest Virus produces changes in behavioral response to apomorphine. Information

Substance Name: Apomorphine

Registry Number: 58-00-4

Grant and Affiliation Information for Microinfusion into the rat brain of antibodies against Semliki Forest Virus produces changes in behavioral response to apomorphine.

AFFILIATION: Department of Molecular Microbiology and Immunology, Brown University Medical School, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA. paul_knopf@brown.edu

Country: Netherlands

AGENCY: United States NINDS

GRANT: R01 NS 40157

ACRONYM: NS

MEDLINETA: J Neuroimmunol

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