Microfluidic patterning for fabrication of contractile cardiac organoids.

Microfluidic patterning for fabrication of contractile cardiac organoids. Research Abstract Details 

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Microfluidic patterning for fabrication of contractile cardiac organoids. Abstract Text:

Ali Khademhosseini,George Eng,Judy Yeh,Peter A Kucharczyk,Robert Langer,Gordana Vunjak-Novakovic,Milica Radisic,

The development of in vitro methods of engineering three-dimensional cardiac tissues can be useful for tissue replacement, diagnostics and drug discovery. Here, we introduce the use of patterned hyaluronic acid (HA) substrates generated using microfluidic patterning as a method of fabricating 3D cardiac organoids. HA micropatterns served as inductive templates for organoid assembly. Upon seeding, cardiomyocytes elongated and aligned along the pattern direction attaching preferentially to the glass substrate and the interface between HA patterns and glass substrate. After 3 days in culture, the linearly aligned myocytes detached from the surface and formed contractile cardiac organoids. The procedure can be utilized to simply, rapidly and inexpensively create in vitro cardiac tissue models.

Microfluidic patterning for fabrication of contractile cardiac organoids. Publishing Authors By Initials

A Khademhosseini,G Eng,J Yeh,PA Kucharczyk,R Langer,G Vunjak-Novakovic,M Radisic,

For similar investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research abstracts see: investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research

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Microfluidic patterning for fabrication of contractile cardiac organoids. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biomedical microdevices

VOLUME: 9

Page Numbers: 149-57

Journal Abbreviation:

ISSN: 1387-2176

DAY: 3

MONTH: Apr

YEAR: 2007

Microfluidic patterning for fabrication of contractile cardiac organoids. Information

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LANGUAGE: eng

NlmUniqueID: 100887374

Microfluidic patterning for fabrication of contractile cardiac organoids. Keywords Mesh Terms:

KEYWORDS: Tissue Engineering

MESH TERMS: methods

Chemical & Substance for Abstract: Microfluidic patterning for fabrication of contractile cardiac organoids. Information

Substance Name: poly(dimethylsiloxane)-polyamide copolym

Registry Number: 0

Grant and Affiliation Information for Microfluidic patterning for fabrication of contractile cardiac organoids.

AFFILIATION: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01HL076485

ACRONYM: HL

MEDLINETA: Biomed Microdevices

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