Microenvironmental regulation of cancer development.

Microenvironmental regulation of cancer development. Research Abstract Details 

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Microenvironmental regulation of cancer development. Abstract Text:

Numerous studies have demonstrated that the tumor microenvironment not only responds to and supports carcinogenesis, but also actively contributes to tumor initiation, progression, and metastasis. During tumor progression all cells composing the tumor undergo phenotypic and epigenetic changes. Paracrine signaling between epithelial and stromal cells is important for the regulation of the proliferation, invasive, angiogenic, and metastatic behavior of cancer cells. Better understanding the molecular mechanisms by which stromal cells exert these effects may open up new venues for cancer therapeutic and preventative interventions.

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Microenvironmental regulation of cancer development. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current opinion in genetics & development

VOLUME: 18

Page Numbers: 27-34

Journal Abbreviation: Curr. Opin. Genet. Dev.

ISSN: 0959-437X

DAY: 20

MONTH: 02

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 9111375

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Grant and Affiliation Information for Microenvironmental regulation of cancer development.

AFFILIATION: Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, D740C, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.

Country: England

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MEDLINETA: Curr Opin Genet Dev

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