Microenvironmental regulation of biomacromolecular therapies.

Microenvironmental regulation of biomacromolecular therapies. Research Abstract Details 

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Microenvironmental regulation of biomacromolecular therapies. Abstract Text:

Hyun Joon Kong,David J Mooney,

There is currently great interest in molecular therapies to treat various diseases, and this has prompted extensive efforts to achieve target-specific and controlled delivery of bioactive macromolecules (for example, proteins, antibodies, DNA and small interfering RNA) through the design of smart drug carriers. By contrast, the influence of the microenvironment in which the target cell resides and the effect it might have on the success of biomacromolecular therapies has been under-appreciated. The extracellular matrix (ECM) component of the cellular niche may be particularly important, as many diseases and injury disrupt the normal ECM architecture, the cell adhesion to ECM, and the subsequent cellular activities. This Review will discuss the importance of the ECM and the ECM-cell interactions on the cell response to bioactive macromolecules, and suggest how this information could lead to new criteria for the design of novel drug delivery systems.

Microenvironmental regulation of biomacromolecular therapies. Publishing Authors By Initials

HJ Kong,DJ Mooney,

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Microenvironmental regulation of biomacromolecular therapies. Journal Published:

PUBLICATION TYPE: Review

Journal: Nature reviews. Drug discovery

VOLUME: 6

Page Numbers: 455-63

Journal Abbreviation:

ISSN: 1474-1776

DAY: 3

MONTH: Jun

YEAR: 2007

Microenvironmental regulation of biomacromolecular therapies. Information

Number of References: 140

LANGUAGE: eng

NlmUniqueID: 101124171

Microenvironmental regulation of biomacromolecular therapies. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Microenvironmental regulation of biomacromolecular therapies. Information

Substance Name: Proteins

Registry Number: 0

Grant and Affiliation Information for Microenvironmental regulation of biomacromolecular therapies.

AFFILIATION: Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.

Country: England

AGENCY: United States NIDCR

GRANT: R37 DE013033

ACRONYM: DE

MEDLINETA: Nat Rev Drug Discov

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