Microarrays for public health: genomic epidemiology of tuberculosis.

Microarrays for public health: genomic epidemiology of tuberculosis. Research Abstract Details 

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Microarrays for public health: genomic epidemiology of tuberculosis. Abstract Text:

In response to a large local school-based outbreak of tuberculosis, we have been evaluating the utility of microarray bacterial genomic analysis in outbreak management. After initial comparison of the isolate from the index case with Mycobacterium tuberculosis H37Rv, it was possible to design robust PCRs directed towards strain-specific deletions. Rapid PCR analysis of isolates proved valuable in determining whether or not other isolates were compatible with the outbreak strain and further microarray studies revealed genetic markers that could be used to discriminate between locally circulating strains.We suggest that this approach forms the basis for developing rapid local genotyping schemes applicable to M. tuberculosis and that application to other pathogens warrants consideration.

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Microarrays for public health: genomic epidemiology of tuberculosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Comparative and functional genomics

VOLUME: 3

Page Numbers: 362-5

Journal Abbreviation: Comp. Funct. Genomics

ISSN: 1531-6912

DAY: 16

MONTH: 07

YEAR: 2002

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LANGUAGE: eng

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AFFILIATION: Department of Microbiology and Immunology Medical Sciences Building PO Box 138 University Road Leicester LE1 9HN UK.

Country: Egypt

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MEDLINETA: Comp Funct Genomics

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